In vivo selection of Campylobacter isolates with high levels of fluoroquinolone resistance associated with gyrA mutations and the function of the CmeABC efflux pump

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dc.authorscopusid7103323810
dc.authorscopusid7004540340
dc.authorscopusid36610236900
dc.authorscopusid7101851942
dc.authorscopusid7407969105
dc.contributor.authorLuo, Naidan
dc.contributor.authorSahin, Orhan
dc.contributor.authorLin, Jun
dc.contributor.authorMichel, Linda O.
dc.contributor.authorZhang, Qijing
dc.date.accessioned2024-09-19T15:48:50Z
dc.date.available2024-09-19T15:48:50Z
dc.date.issued2003
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractEnrofloxacin treatment of chickens infected with fluoroquinolone (FQ)-sensitive Campylobacter promoted the emergence of FQ-resistant Campylobacter mutants which propagated in the intestinal tract and recolonized the chickens. The recovered isolates were highly resistant to quinolone antibiotics but remained susceptible to non-FQ antimicrobial agents. Specific single-point mutations in the gyrA gene and the function of the CmeABC efflux pump were linked to the acquired FQ resistance. These results reveal that Campylobacter is hypermutable in vivo under the selection pressure of FQ and highlight the need for the prudent use of FQ antibiotics.en_US
dc.identifier.doi10.1128/AAC.47.1.390-394.2003
dc.identifier.endpage394en_US
dc.identifier.issn0066-4804
dc.identifier.issue1en_US
dc.identifier.pmid12499221en_US
dc.identifier.scopus2-s2.0-12244305604en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage390en_US
dc.identifier.urihttps://doi.org/10.1128/AAC.47.1.390-394.2003
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15329
dc.identifier.volume47en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofAntimicrobial Agents and Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnimalsen_US
dc.subjectAnti-Infective Agentsen_US
dc.subjectCampylobacter Infectionsen_US
dc.subjectCampylobacter jejunien_US
dc.subjectChickensen_US
dc.subjectCiprofloxacinen_US
dc.subjectDNA Gyraseen_US
dc.subjectDrug Resistance, Microbialen_US
dc.subjectFluoroquinolonesen_US
dc.subjectMicrobial Sensitivity Testsen_US
dc.subjectMutationen_US
dc.subjectNalidixic Aciden_US
dc.subjectQuinolonesen_US
dc.subjectciprofloxacinen_US
dc.subjectenrofloxacinen_US
dc.subjectquinoline derived antiinfective agenten_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectantibiotic resistanceen_US
dc.subjectantibiotic sensitivityen_US
dc.subjectarticleen_US
dc.subjectbacterial colonizationen_US
dc.subjectbacterium isolateen_US
dc.subjectbacterium mutanten_US
dc.subjectCampylobacteren_US
dc.subjectchickenen_US
dc.subjectgene mutationen_US
dc.subjectGram negative infectionen_US
dc.subjectintestineen_US
dc.subjectminimum inhibitory concentrationen_US
dc.subjectnonhumanen_US
dc.subjectpriority journalen_US
dc.titleIn vivo selection of Campylobacter isolates with high levels of fluoroquinolone resistance associated with gyrA mutations and the function of the CmeABC efflux pumpen_US
dc.typeArticleen_US

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