Investigation of the sperm aquaporin molecules expression in fertile and infertile men

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dc.contributor.authorGevrek, Fikret
dc.contributor.authorAkyoruk, Arif
dc.contributor.authorKara, Mikail
dc.contributor.authorKatar, Muzaffer
dc.contributor.authorErdemir, Fikret
dc.date.accessioned2024-09-19T16:26:48Z
dc.date.available2024-09-19T16:26:48Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Ăśniversitesien_US
dc.description.abstractAim: Infertility is pregnancy failure for a year without protection, despite regular sexual intercourse. Various disorders and deficiencies in both genders can cause this situation, and a considerable portion of these cases consists of male infertility. We aimed to investigate the relationship between aquaporin molecules expressed in human sperm cells and male infertility. Materials and Methods: We carried out the study on the sperm cells of two different groups consisting of ten fertile and twenty infertile men older than eighteen. Smear slides were prepared following spermiogram testing. These slides were stained using the Diffquick and immunohistochemistry protocols to test the Kruger strict sperm morphology and detect the immune expression of the AQP molecules, respectively. Results: The results of the spermiogram and Kruger-strict sperm morphology analysis showed that average sperm cell count and numerical sperm parameters values in the semen of infertile individuals decreased, and sperm counts with anomalies were higher in infertile ones versus those of fertile (p<0.05) as predicted. Our immunohistochemical analysis findings revealed that the immune expression of each aquaporin molecule was reduced slightly in infertile men regarding fertile ones, but the decrease was not statistically significant (p>0.05). Conclusion: According to our findings, the immune expression of infertile ones’ aquaporin molecules was reduced by a small amount, even if this was not statistically meaningful. These molecules of the sperm cells can not be primarily associated with male infertility. However, further advanced-level research is required on this issue to make a precise decision.en_US
dc.identifier.doi10.5455/annalsmedres.2023.06.127
dc.identifier.endpage898en_US
dc.identifier.issn2636-7688
dc.identifier.issue8en_US
dc.identifier.startpage893en_US
dc.identifier.trdizinid1205785en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2023.06.127
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1205785
dc.identifier.urihttps://hdl.handle.net/20.500.12483/16365
dc.identifier.volume30en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAquaporinsen_US
dc.subjectFertileen_US
dc.subjectImmune expressionen_US
dc.subjectInfertileen_US
dc.subjectSpermen_US
dc.titleInvestigation of the sperm aquaporin molecules expression in fertile and infertile menen_US
dc.typeArticleen_US

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