Could early septal involvement in the remodeling process be related to the advance hypertensive heart disease?

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dc.authoridKucukler, Nagehan/0000-0002-9867-266X
dc.contributor.authorYalcin, Fatih
dc.contributor.authorTopaloglu, Caner
dc.contributor.authorKucukler, Nagehan
dc.contributor.authorOfgeli, Mehmet
dc.contributor.authorAbraham, Theodore P.
dc.date.accessioned2024-09-18T20:55:43Z
dc.date.available2024-09-18T20:55:43Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Quantitative imaging analyses showed an earlier septal wall involvement in hypertension. We planned to determine the effect of hypertension on regionalmyocardial performance index (MPI) in a hypertensive patient population. Methods: We evaluated 119 hypertensive patients who were divided into gr. I:57 patients without left ventricular hypertrophy (LVH), (53.1 +/- 10 years), and gr.II:62 patients with LVH (55.1 +/- 9 years) using conventional and tissue doppler imaging. They were compared with gr. III, a sex-age-matched normal control group (37 subjects, 53.0 +/- 10 years). Results: We detected basal septal and basal lateral contraction time (CT), isovolumetric CT and relaxation time (IVRT) and MPI. EF was 68 +/- 5 % in gr. I, 69 +/- 5 % in gr. II, 69 +/- 4 % in gr. III. LV mass index was 122 +/- 11 g/m2 in gr. I, 148 +/- 13 g/m2 in gr. II and 118 +/- 13 g/m2 in gr. III. Concentric LVH was detected in gr. II (relative wall thickness=0.49 +/- 0.8). LV septal and lateral MPI were abnormal in both hypertensive groups (p < 0.0001). Septal MPI was correlated moderately with septal wall thickness (r = 0.447, p < 0.001). Conclusions: LV diastolic dysfunction becomes more severe in septal wall than lateral wall in hypertensive LVH. Septal myocardial performance is more dominantly affected by hypertension possibly due to earlier septal involvement in disease course. Septal MPI is correlated moderately with septal wall thickness. (C) 2015 Published by Elsevier Ireland Ltd.en_US
dc.description.sponsorshipU.S. Government Fulbright scholarshipen_US
dc.description.sponsorshipThis study has been presented at the 2011 annual meeting of the American Heart Association, Orlando, FL (Circulation 124; A11796). FY is supported by the U.S. Government Fulbright scholarship.en_US
dc.identifier.doi10.1016/j.ijcha.2015.04.003
dc.identifier.endpage145en_US
dc.identifier.issn2352-9067
dc.identifier.pmid28785662en_US
dc.identifier.scopus2-s2.0-84930647203en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijcha.2015.04.003
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12018
dc.identifier.volume7en_US
dc.identifier.wosWOS:000218791700029en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofIjc Heart & Vasculatureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRegional myocardial performanceen_US
dc.subjectRegional myocardial remodelingen_US
dc.subjectHypertensive heart diseaseen_US
dc.titleCould early septal involvement in the remodeling process be related to the advance hypertensive heart disease?en_US
dc.typeArticleen_US

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