Investigation of the neuroprotective effect of kefir in experimental spinal cord injury

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dc.authoridOzsoy, Bulent/0000-0003-0045-3790
dc.contributor.authorYurtal, Ziya
dc.contributor.authorKutlu, Tuncer
dc.contributor.authorAltug, Muhammed Enes
dc.contributor.authorOzsoy, Bulent
dc.contributor.authorAlakus, Halil
dc.contributor.authorYurdagul Ozsoy, Sule
dc.date.accessioned2024-09-18T20:28:15Z
dc.date.available2024-09-18T20:28:15Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.descriptionInternational Veterinary Pathology Congress -- OCT 27-31, 2020 -- ELECTR NETWORKen_US
dc.description.abstractIn this study, the antioxidant, anti-inflammatory, and neuroprotective effects of kefir were investigated in spinal cord injury that was experimentally created on rats with a compression trauma model. A total of 56 Wistar-Albino male rats were used in the study. Daily freshly prepared 18 ml/kg/day of kefir was given by oral gavage to animals 7 days before and during the trauma and during the trauma. Spinal cord injury was created according to the weight drop method. On the 1st and 7th days before euthanasia, intracardiac blood was collected for analysis, and then they were sacrificed. The damaged spinal cord segments were examined biochemically, immunohistochemically, and histopathologically. When compared to the sham groups, kefir had a positive effect in the preconditioning and treatment groups by decreasing spinal cord bleeding, edema, myelin sheath damage, liquefactive necrosis, neuronal necrosis, selectivity of canalis centralis, and gitter cell levels significantly. When compared to the sham groups, kefir was found to have a positive effect in the treatment groups by decreasing the neuron specific enolase (NSE), ionized calcium binding adapter molecule 1 (IBA-1), inducible nitric oxide synthase (INOS), cyclooxygenase 2 (COX-2) and myelin basic protein (MBP) levels significantly on the 1st and 7th days, and by increasing the glial fibrillary acidic protein (GFAP) level significantly. As a result, it was demonstrated that kefir had a protective and therapeutic effect on spinal cord injury.en_US
dc.description.sponsorshipCoordinatorship of Scientific Research Projects of Hatay Mustafa Kemal University [18]en_US
dc.description.sponsorshipThis work was supported by the Coordinatorship of Scientific Research Projects of Hatay Mustafa Kemal University [grant numbers 18.M.021].en_US
dc.identifier.doi10.33988/auvfd.872947
dc.identifier.endpage19en_US
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85145050078en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage9en_US
dc.identifier.trdizinid1152563en_US
dc.identifier.urihttps://doi.org/10.33988/auvfd.872947
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1152563
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10809
dc.identifier.volume70en_US
dc.identifier.wosWOS:001047216600002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAnkara Univen_US
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKefiren_US
dc.subjectNeuroprotective agentsen_US
dc.subjectSpinal cord injuriesen_US
dc.titleInvestigation of the neuroprotective effect of kefir in experimental spinal cord injuryen_US
dc.typeConference Objecten_US

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