Carcinogenicity of many chemical agents
[ N/A ]
Tarih
2002
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Epidemiologic and experimental findings show that many natural and synthetic chemicals may lead to permanent genetic alterations in cells. Furthermore, a strong association has been found between mutagenicity and carcinogenicity of many chemical agents; accordingly, mutations in somatic cells can indicate potential carcinogenicity. Experimental and some epidemiological data suggests, that carcinogenesis is a multistep process that initiation process irreversibly transformed a number of cells into latent tumor cells and the number depending on the carcinogenic potency of the chemical agent. It was also demostrated that the latent tumour cells would remain dormont until application of the promoting agent that promoters alone were unable to do this, but initiated cells to proliferate and develop into tumours. It was postulated that initiation and promotion stage of neoplastic development were part of a large and continuous process of progression that may lead to malignancy. It appears, therefore, that the chemicals are an important causes of carcinogenesis, however the role of chemicals is more complex since some agents can combine chemically with nucleophilic sites in target molecules, including DNA, RNAs and proteins.
Açıklama
Anahtar Kelimeler
chemical agent, carcinogenesis, carcinogenicity, cell proliferation, gene mutation, malignant transformation, mutagenicity, review, somatic cell, tumor cell
Kaynak
SENDROM
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
14
Sayı
10
