Carcinogenicity of many chemical agents

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dc.authorscopusid6603239626
dc.contributor.authorÖztaş, Haydar
dc.date.accessioned2024-09-19T15:49:50Z
dc.date.available2024-09-19T15:49:50Z
dc.date.issued2002
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractEpidemiologic and experimental findings show that many natural and synthetic chemicals may lead to permanent genetic alterations in cells. Furthermore, a strong association has been found between mutagenicity and carcinogenicity of many chemical agents; accordingly, mutations in somatic cells can indicate potential carcinogenicity. Experimental and some epidemiological data suggests, that carcinogenesis is a multistep process that initiation process irreversibly transformed a number of cells into latent tumor cells and the number depending on the carcinogenic potency of the chemical agent. It was also demostrated that the latent tumour cells would remain dormont until application of the promoting agent that promoters alone were unable to do this, but initiated cells to proliferate and develop into tumours. It was postulated that initiation and promotion stage of neoplastic development were part of a large and continuous process of progression that may lead to malignancy. It appears, therefore, that the chemicals are an important causes of carcinogenesis, however the role of chemicals is more complex since some agents can combine chemically with nucleophilic sites in target molecules, including DNA, RNAs and proteins.en_US
dc.identifier.endpage130en_US
dc.identifier.issn1016-5134
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-0036811606en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15437
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofSENDROMen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchemical agenten_US
dc.subjectcarcinogenesisen_US
dc.subjectcarcinogenicityen_US
dc.subjectcell proliferationen_US
dc.subjectgene mutationen_US
dc.subjectmalignant transformationen_US
dc.subjectmutagenicityen_US
dc.subjectreviewen_US
dc.subjectsomatic cellen_US
dc.subjecttumor cellen_US
dc.titleCarcinogenicity of many chemical agentsen_US
dc.title.alternativeBazi kimyasal maddeler ve kanserojen özelliklerien_US
dc.typeReview Articleen_US

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