Asymmetric Henry reactions catalyzed by metal complexes of chiral oxazoline based ligands
Yükleniyor...
Tarih
2013
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Chiral oxazolines have been synthesized from norephedrine and pyrrole nitrile or benzoyl chloride and applied to the catalytic asymmetric Henry reactions of p-nitro aldehydes with nitromethane to provide beta-hydroxy nitroalkanols in high conversion (up to 92%). The reaction was then optimized in terms of the metal, solvent, temperature, and amount of chiral ligand. The corresponding catalyst with Cu(OTf)(2) and isopropanol as the solvent gave the best enantioselectivities (up to 84% ee) of the corresponding beta-nitroalkanol for p-nitrobenzaldehyde. (C) 2012 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Enantioselective Nitroaldol Reaction, Microwave-Assisted Synthesis, One-Pot Conversion, Bis(Oxazoline) Ligands, Efficient Synthesis, Facile Synthesis, Amino-Alcohols, Solvent-Free, Aldehydes, 2-Imidazolines
Kaynak
Tetrahedron-Asymmetry
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
24
Sayı
1
