Characteristics of patients with hepatocellular carcinoma: A multicenter study

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dc.authoridAdali, Gupse/0000-0003-2157-0304
dc.authoridALTINTAS, ENGIN/0000-0003-0796-1456
dc.authoridSimsek, Cem/0000-0002-7037-5233
dc.authoridTuran Gokce, Dilara/0000-0003-3660-7237
dc.authoridGuzelbulut, Fatih/0000-0003-4889-208X
dc.contributor.authorGuzelbulut, Fatih
dc.contributor.authorKaraogullarindan, Umit
dc.contributor.authorAkkiz, Hikmet
dc.contributor.authorAltintas, Engin
dc.contributor.authorDemirtas, Coskun Ozer
dc.contributor.authorBahadir, Ozgur
dc.contributor.authorKeklikkiran, Caglayan
dc.date.accessioned2024-09-18T20:11:30Z
dc.date.available2024-09-18T20:11:30Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground and Aim: The aim of the present study was to examine the etiology of hepatocellular carcinoma (HCC) by underlying cause and determine the characteristics and clinical features of patients with HCC. Materials and Methods: The study comprised 1802 HCC patients diagnosed and followed up by Liver Diseases Outpatient Clinics in 14 tertiary centers in Turkey between 2001 and 2020. Results: The mean age was 62.3 +/- 10.7 years, and 78% of them were males. Of the patients, 82% had cirrhosis. Hepatitis B virus (HBV) infection was the most common etiology (54%), followed by hepatitis C virus (HCV) infection (19%) and nonalcoholic fatty liver disease (NAFLD) (10%). Of the patients, 56% had a single lesion. Macrovascular invasion and extrahepatic spread were present in 15% and 12% of the patients, respectively. The median serum alpha-fetoprotein level was 25.4 ng/mL. In total, 39% of the patients fulfilled the Milan Criteria. When we compared the characteristics of patients diagnosed before and after January 2016, the proportion of NAFLD-related HCC cases increased after 2016, from 6.6% to 13.4%. Conclusion: Chronic HBV and HCV infections remain the main causes of HCC in Turkey. The importance of NAFLD as a cause of HCC is increasing.en_US
dc.identifier.doi10.14744/hf.2022.2022.0028
dc.identifier.endpage76en_US
dc.identifier.issn1307-5888
dc.identifier.issn2757-7392
dc.identifier.issue3en_US
dc.identifier.pmid36177097en_US
dc.identifier.scopus2-s2.0-85164366407en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage71en_US
dc.identifier.trdizinid1173796en_US
dc.identifier.urihttps://doi.org/10.14744/hf.2022.2022.0028
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1173796
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8907
dc.identifier.volume3en_US
dc.identifier.wosWOS:000863556400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofHepatology Forumen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectClinical characteristicsen_US
dc.subjectetiologyen_US
dc.subjecthepatocellular carcinomaen_US
dc.titleCharacteristics of patients with hepatocellular carcinoma: A multicenter studyen_US
dc.typeArticleen_US

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