Aşırı aktif mesane tedavisinde, Trospiyum klorid ve Tolterodin'in tedavi etkinlikleri ve yan etkilerinin karşılaştırılması
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Tarih
2008
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Dergi ISSN
Cilt Başlığı
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
AMAÇ: Aşırı aktif mesane şikayetleri olan hastalarda iki anti-muskarinik ajanın (Trospiyum Klorid ve Tolterodine-L- Tartarat ) etkinliğinin ve yan etki profillerinin karşılaştırılması. MATERYAL-METOD: 2005 yılı boyunca, Tıp Fakültesi Jinekoloji Polikliniğimiz’e sıkışma inkontinansı şikayeti ile başvuran ve aşırı aktif mesane değerlendirme anket formunu dolduran, Tolterodin-L- Tartarat (Detrusitol ®) 2 mg tb 2x1 (n: 38) ve Trospiyum Klorid (Spazmex ®) 30 mg tb 2x1 (n: 41) kullanan hastalar retrospektif olarak değerlendirildi. Her iki ajanı alan hastalar, tedavinin başlangıcından 1 ve 3 ay sonra, anket formundaki sorulara göre ajanların etkinliği ve yan etkileri açısından puan verilerek değerlendirildi. BULGULAR: Her iki tedavi grubunun yaş, gravida, parite gibi demografik verileri istatiksel olarak benzerdi (p >0.05). Her iki grupta da tedavi sonrası puanların, tedavi öncesi puanlardan anlamlı olarak düşük olduğu gözlendi (p <0.001). Her iki ajana ait tedavi etkinlikleri ve yan etki görülme oranları istatistiksel olarak benzer bulundu (p >0.05).
OBJECTIVE: To compare the efficacy and adverse effects of two antimuscarinic agents ( trospium chloride (TCl), tolterodine L-tartrate) in patients having overactive bladder symptoms. MATERIAL-METHODS: During 2005, patients admitted with urge incontinence to Faculty of Medicine, Gynaecology Clinic and answered overactive bladder evaluation questionnaire form, and given Tolterodine-L- Tartrate (Detrusitol ®) 2 mg, 2x1 (n: 38), Trospium chloride (Spazmex ®) 30 mg tb 2x1 (n: 41), were retrospectively evaluated. Patients taken both drugs were determined by giving points regarding efficacy and adverse effects as questioned in the questionnaire form at the 1st and 3rd months following the initiation of treatment. RESULTS: Demografic data were similar in both groups (p>0.05). Points given after treatment were found significantly lower than the points given before treatment in both groups (p<0.001). The efficacy and adverse effects of both drugs were found statisticaly similar (p>0.05). CONCLUSION: In the highligths of retrospevtive data, we concluded that Trospium chloride and Tolterodine may be used alternatively to each other in treatment of overactive bladder.
OBJECTIVE: To compare the efficacy and adverse effects of two antimuscarinic agents ( trospium chloride (TCl), tolterodine L-tartrate) in patients having overactive bladder symptoms. MATERIAL-METHODS: During 2005, patients admitted with urge incontinence to Faculty of Medicine, Gynaecology Clinic and answered overactive bladder evaluation questionnaire form, and given Tolterodine-L- Tartrate (Detrusitol ®) 2 mg, 2x1 (n: 38), Trospium chloride (Spazmex ®) 30 mg tb 2x1 (n: 41), were retrospectively evaluated. Patients taken both drugs were determined by giving points regarding efficacy and adverse effects as questioned in the questionnaire form at the 1st and 3rd months following the initiation of treatment. RESULTS: Demografic data were similar in both groups (p>0.05). Points given after treatment were found significantly lower than the points given before treatment in both groups (p<0.001). The efficacy and adverse effects of both drugs were found statisticaly similar (p>0.05). CONCLUSION: In the highligths of retrospevtive data, we concluded that Trospium chloride and Tolterodine may be used alternatively to each other in treatment of overactive bladder.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Türk Jinekoloji ve Obstetrik Derneği Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
2
