Jeneralize liken planusta dar -bant UVB tedavisi
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Date
2014
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Access Rights
info:eu-repo/semantics/openAccess
Abstract
Amaç: Liken planus (LP) sık görülen inflamatuar bir deri hastalığıdır. Son zamanlarda dar-bant ultraviyole B (UVB) fototerapisinin LP tedavisinde etkili olduğu bildirilmektedir. Bu çalışmada jeneralize LP’li hastalarda dar-bant UVB tedavisinin etkinliği ve güvenilirliğinin değerlendirilmesi amaçlanmıştır. Yöntem : Çalışmamızda Ocak 2009 ve Aralık 2012 tarihleri arasında kliniğimiz fototerapi ünitesinde LP tanısı ile tedavi gören hastalara ait veriler retrospektif olarak incelendi. Klinik yanıt, sırasıyla lezyonlardaki iyileşme % 90 ve üzerinde, 51 -89%, 21 -50% ve % 20'nin altında olduğunda, "tam yanıt", "kısmi yanıt", "az yanıt" ya da "yanıt yok" olarak adlandırıldı. Bulgular: Çalışmaya 9 -71 yaş arasında 20 hasta alındı. Hastaların hastalık süreleri 1 -84 ay arasında değişmekteydi ve hastaların %30’unun ek bir sistemik hastalığı vardı. On iki hastada (%60) tam yanıt, beş hastada (%25) kısmi yanıt, bir hastada (%5) az yanıt saptandı ancak iki hastada (%10) tedaviye yanıt elde edilemedi. Total seans sayısı ortalaması 45,2 ± 16,4 (18 -80) ve total kümülatif doz ortalaması 54,6 ± 34,2 J/cm 2 olarak belirlendi. Klinik tam yanıt ortalama 37,7 (24 -50) seansta elde edildi. Fototerapiye bağlı akut yan etkiler sadece üç hastada izlendi. Sonuç : Dar-bant UVB fototerapisi, jeneralize LP tedavisinde etkili ve güvenilir bir tedavi yöntemidir.
Objective : Lichen planus (LP) is a common inflammatory skin disease. Recently, narrow-band ultraviolet B (UVB) phototherapy has been re ported to be effective in the treatment of LP. In this study, we aimed to evaluate the efficacy and safety of the narrow -band UVB phototherapy in patients with generalized LP. Method : In our study, the data of the patients with LP who were treated in our c linic’s phototherapy unit from between January 2009 and December 2012 were analyzed retrospectively. Clinical response was named as "complete response”, "partial response”, "poor response” or “no response” when the improvement of the lesions is 90% and hig her, 51 -89%, 21 -50% and below 20%, respectively. Results : The study included 20 patients between the ages of 9 - 71. Duration of disease of the patients ranged from 1 -84 months and 30% of the patients had an additional systemic disease. Twelve patients had c omplete response (60%), five patients (25%) had partial response, and one patient had little response (10%) but the response to treatment could not be obtained in two patients (5%). The mean total number of sessions was 45.2 ± 16.4 (18 -80) and the mean tot al cumulative dose was 54.6 ± 34.2 J/cm 2 . Clinical complete response was obtained at average 37.7 (24 -50) sessions. Acute side effects of phototherapy were observed only in three patients. Conclusion : Narrow -band UVB phototherapy is an effective and safe treatment modality in the treatment of generalized LP.
Objective : Lichen planus (LP) is a common inflammatory skin disease. Recently, narrow-band ultraviolet B (UVB) phototherapy has been re ported to be effective in the treatment of LP. In this study, we aimed to evaluate the efficacy and safety of the narrow -band UVB phototherapy in patients with generalized LP. Method : In our study, the data of the patients with LP who were treated in our c linic’s phototherapy unit from between January 2009 and December 2012 were analyzed retrospectively. Clinical response was named as "complete response”, "partial response”, "poor response” or “no response” when the improvement of the lesions is 90% and hig her, 51 -89%, 21 -50% and below 20%, respectively. Results : The study included 20 patients between the ages of 9 - 71. Duration of disease of the patients ranged from 1 -84 months and 30% of the patients had an additional systemic disease. Twelve patients had c omplete response (60%), five patients (25%) had partial response, and one patient had little response (10%) but the response to treatment could not be obtained in two patients (5%). The mean total number of sessions was 45.2 ± 16.4 (18 -80) and the mean tot al cumulative dose was 54.6 ± 34.2 J/cm 2 . Clinical complete response was obtained at average 37.7 (24 -50) sessions. Acute side effects of phototherapy were observed only in three patients. Conclusion : Narrow -band UVB phototherapy is an effective and safe treatment modality in the treatment of generalized LP.
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3
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1
