Caffeic acid phenetyl ester accelerates cutaneous wound healing in a rat model and decreases oxidative stress
Yükleniyor...
Tarih
2007
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background Cutaneous injury causes a depression in antioxidant status, as reactive oxygen species (ROS) are produced in response to injury. Aim To determine the effects of caffeic acid phenethyl ester (CAPE), an antioxidant and anti-inflammatory agent, on wound healing in rats. Methods In total, 40 male rats were divided into two groups: one group treated with CAPE (n = 20) and a second untreated control group (n = 20). A linear full-thickness incision was performed on the back of each rat and sutured. After incision, CAPE was given to the treatment group and saline to the control group. On days 1, 3, 7 and 14, five animals in each group were killed, and wound tissues dissected for biochemical and histopathological analysis. Results Wound tissues showed a significant increase in glutathione and nitric oxide levels, and a significant decrease in malondialdehyde levels and superoxide dismutase levels in the CAPE group compared with the control group. Histopathology of the wound tissues displayed rapid epithelium development in the CAPE group compared with the control group. Conclusions This study has demonstrated that CAPE partly accelerates full-thickness wound healing by its antioxidant and ROS-scavenging capabilities.
Açıklama
Anahtar Kelimeler
Lipid-Peroxidation, Nitric-Oxide, Vitamin-E, Glutathione, Plasma, Blood, Serum
Kaynak
Clinical and Experimental Dermatology
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
32
Sayı
6