Caffeic acid phenetyl ester accelerates cutaneous wound healing in a rat model and decreases oxidative stress

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dc.contributor.authorSerarslan, G.
dc.contributor.authorAltug, E.
dc.contributor.authorKontas, T.
dc.contributor.authorAtik, E.
dc.contributor.authorAvci, G.
dc.date.accessioned2024-09-18T21:05:15Z
dc.date.available2024-09-18T21:05:15Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground Cutaneous injury causes a depression in antioxidant status, as reactive oxygen species (ROS) are produced in response to injury. Aim To determine the effects of caffeic acid phenethyl ester (CAPE), an antioxidant and anti-inflammatory agent, on wound healing in rats. Methods In total, 40 male rats were divided into two groups: one group treated with CAPE (n = 20) and a second untreated control group (n = 20). A linear full-thickness incision was performed on the back of each rat and sutured. After incision, CAPE was given to the treatment group and saline to the control group. On days 1, 3, 7 and 14, five animals in each group were killed, and wound tissues dissected for biochemical and histopathological analysis. Results Wound tissues showed a significant increase in glutathione and nitric oxide levels, and a significant decrease in malondialdehyde levels and superoxide dismutase levels in the CAPE group compared with the control group. Histopathology of the wound tissues displayed rapid epithelium development in the CAPE group compared with the control group. Conclusions This study has demonstrated that CAPE partly accelerates full-thickness wound healing by its antioxidant and ROS-scavenging capabilities.en_US
dc.identifier.doi10.1111/j.1365-2230.2007.02470.x
dc.identifier.endpage715en_US
dc.identifier.issn0307-6938
dc.identifier.issn1365-2230
dc.identifier.issue6en_US
dc.identifier.pmid17953639en_US
dc.identifier.scopus2-s2.0-35349027757en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage709en_US
dc.identifier.urihttps://doi.org/10.1111/j.1365-2230.2007.02470.x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13474
dc.identifier.volume32en_US
dc.identifier.wosWOS:000250252400022en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical and Experimental Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectNitric-Oxideen_US
dc.subjectVitamin-Een_US
dc.subjectGlutathioneen_US
dc.subjectPlasmaen_US
dc.subjectBlooden_US
dc.subjectSerumen_US
dc.titleCaffeic acid phenetyl ester accelerates cutaneous wound healing in a rat model and decreases oxidative stressen_US
dc.typeArticleen_US

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