Evidence for negative effects of elevated intra-abdominal pressure on pulmonary mechanics and oxidative stress
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Dosyalar
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Hindawi Publishing Corporation
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective. To compare the effects of pneumoperitoneum on lung mechanics, end-tidal CO(ETCO, arterial blood gases (ABG), and oxidative stress markers in blood and bronchoalveolar lavage fluid (BALF) during laparoscopic cholecystectomy (LC) by using lung-protective ventilation strategy. Materials and Methods. Forty-six patients undergoing LC and abdominal wall hernia (AWH) surgery were assigned into 2 groups. Measurements and blood samples were obtained before, during pneumoperitoneum, and at the end of surgery. BALF samples were obtained after anesthesia induction and at the end of surgery. Results. Peak inspiratory pressure, ETCO and pCOvalues at the 30th minute were significantly increased, while there was a significant decrease in dynamic lung compliance, pH, and pOvalues in LC group. In BALF samples, total oxidant status (TOS), arylesterase, paraoxonase, and malondialdehyde levels were significantly increased; the glutathione peroxidase levels were significantly decreased in LC group. The serum levels of TOS and paraoxonase were significantly higher at the end of surgery in LC group. In addition, arylesterase level in the 30th minute was increased compared to baseline. Serum paraoxonase level at the end of surgery was significantly increased when compared to AWH group. Conclusions. Our study showed negative effects of pneumoperitoneum in both lung and systemic levels despite lung-protective ventilation strategy. © 2015 I. Davarci et al.
Açıklama
Anahtar Kelimeler
Adult, Aryldialkylphosphatase, Blood Gas Analysis, Bronchoalveolar Lavage Fluid, Carboxylic Ester Hydrolases, Cholecystectomy, Laparoscopic, Female, Glutathione Peroxidase, Humans, Male, Malondialdehyde, Oxidative Stress, Pneumoperitoneum, Prospective Studies, Respiratory Mechanics, Toscana virus, aryldialkylphosphatase, arylesterase, glutathione peroxidase, malonaldehyde, aryldialkylphosphatase, arylesterase, carboxylesterase, glutathione peroxidase, malonaldehyde, abdominal pressure, abdominal wall hernia, adult, aged, anesthesia induction, arterial gas, Article, blood sampling, carbon dioxide tension, cholecystectomy, clinical article, controlled study, female, human, lung compliance, lung lavage, lung mechanics, lung ventilation, male, oxidative stress, peak inspiratory flow, pH, pneumoperitoneum, adverse effects, blood gas analysis, breathing mechanics, bronchoalveolar lavage fluid, chemistry, complication, laparoscopic cholecystectomy, metabolism, oxidative stress, pathophysiology, physiology, pneumoperitoneum, prospective study
Kaynak
Scientific World Journal
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
2015
