Evidence for negative effects of elevated intra-abdominal pressure on pulmonary mechanics and oxidative stress

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dc.authorscopusid25721961000
dc.authorscopusid56358237700
dc.authorscopusid55337167600
dc.authorscopusid13613040200
dc.authorscopusid16048705200
dc.authorscopusid34875451400
dc.authorscopusid55507626600
dc.contributor.authorDavarci, I.
dc.contributor.authorKarcio?lu, M.
dc.contributor.authorTuzcu, K.
dc.contributor.authorInano?lu, K.
dc.contributor.authorYetim, T.D.
dc.contributor.authorMotor, S.
dc.contributor.authorUlutaş, K.T.
dc.date.accessioned2024-09-19T15:48:51Z
dc.date.available2024-09-19T15:48:51Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective. To compare the effects of pneumoperitoneum on lung mechanics, end-tidal CO(ETCO, arterial blood gases (ABG), and oxidative stress markers in blood and bronchoalveolar lavage fluid (BALF) during laparoscopic cholecystectomy (LC) by using lung-protective ventilation strategy. Materials and Methods. Forty-six patients undergoing LC and abdominal wall hernia (AWH) surgery were assigned into 2 groups. Measurements and blood samples were obtained before, during pneumoperitoneum, and at the end of surgery. BALF samples were obtained after anesthesia induction and at the end of surgery. Results. Peak inspiratory pressure, ETCO and pCOvalues at the 30th minute were significantly increased, while there was a significant decrease in dynamic lung compliance, pH, and pOvalues in LC group. In BALF samples, total oxidant status (TOS), arylesterase, paraoxonase, and malondialdehyde levels were significantly increased; the glutathione peroxidase levels were significantly decreased in LC group. The serum levels of TOS and paraoxonase were significantly higher at the end of surgery in LC group. In addition, arylesterase level in the 30th minute was increased compared to baseline. Serum paraoxonase level at the end of surgery was significantly increased when compared to AWH group. Conclusions. Our study showed negative effects of pneumoperitoneum in both lung and systemic levels despite lung-protective ventilation strategy. © 2015 I. Davarci et al.en_US
dc.identifier.doi10.1155/2015/612642
dc.identifier.issn2356-6140
dc.identifier.pmid25685845en_US
dc.identifier.scopus2-s2.0-84922364371en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1155/2015/612642
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15333
dc.identifier.volume2015en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.ispartofScientific World Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdulten_US
dc.subjectAryldialkylphosphataseen_US
dc.subjectBlood Gas Analysisen_US
dc.subjectBronchoalveolar Lavage Fluiden_US
dc.subjectCarboxylic Ester Hydrolasesen_US
dc.subjectCholecystectomy, Laparoscopicen_US
dc.subjectFemaleen_US
dc.subjectGlutathione Peroxidaseen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMalondialdehydeen_US
dc.subjectOxidative Stressen_US
dc.subjectPneumoperitoneumen_US
dc.subjectProspective Studiesen_US
dc.subjectRespiratory Mechanicsen_US
dc.subjectToscana virusen_US
dc.subjectaryldialkylphosphataseen_US
dc.subjectarylesteraseen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectmalonaldehydeen_US
dc.subjectaryldialkylphosphataseen_US
dc.subjectarylesteraseen_US
dc.subjectcarboxylesteraseen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectmalonaldehydeen_US
dc.subjectabdominal pressureen_US
dc.subjectabdominal wall herniaen_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectanesthesia inductionen_US
dc.subjectarterial gasen_US
dc.subjectArticleen_US
dc.subjectblood samplingen_US
dc.subjectcarbon dioxide tensionen_US
dc.subjectcholecystectomyen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectlung complianceen_US
dc.subjectlung lavageen_US
dc.subjectlung mechanicsen_US
dc.subjectlung ventilationen_US
dc.subjectmaleen_US
dc.subjectoxidative stressen_US
dc.subjectpeak inspiratory flowen_US
dc.subjectpHen_US
dc.subjectpneumoperitoneumen_US
dc.subjectadverse effectsen_US
dc.subjectblood gas analysisen_US
dc.subjectbreathing mechanicsen_US
dc.subjectbronchoalveolar lavage fluiden_US
dc.subjectchemistryen_US
dc.subjectcomplicationen_US
dc.subjectlaparoscopic cholecystectomyen_US
dc.subjectmetabolismen_US
dc.subjectoxidative stressen_US
dc.subjectpathophysiologyen_US
dc.subjectphysiologyen_US
dc.subjectpneumoperitoneumen_US
dc.subjectprospective studyen_US
dc.titleEvidence for negative effects of elevated intra-abdominal pressure on pulmonary mechanics and oxidative stressen_US
dc.typeArticleen_US

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