Osteopenisi olan ankilozan spondilitli hastalarda kemik mineral yoğunluğu ile hastalık aktivitesi arasındaki ilişkinin değerlendirilmesi
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Tarih
2013
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Ankilozan Spondilit (AS), kronik inflamatuvar bir hastalıktır. Lokal sitokin salınımı ve immobiliteye bağlı olarak AS’de spinal osteopeni yaygındır. Bu çalışmada, osteopenisi olan Ankilozan Spondilitli hastalarda kemik mineral yoğunluğu ile hastalık aktivitesi arasındaki ilişkiyi değerlendirdik. Gereç ve Yöntem: 61 AS’li hasta (26K, 35E) çalışmaya alındı. Hastaların; hastalık süresi, sabah tutukluğu süresi, schober testi, Eritrosit sedimentasyon hızı (ESH) ve C reaktif protein (CRP) değerleri kaydedildi. Hastalık aktivitesi Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ile değerlendirildi. Kemik mineral yoğunluğu (KMY) GE/LUNAR DPX PRO cihazı kullanılarak ölçüldü. Bulgular: Hastaların ortalama yaşı 38,67±10,81, ortalama hastalık süresi 7,87±7,09 yıl idi. 34 (%55,7) hastada osteopeni vardı. Bu hastaların ortalama lomber ve femur KMY değerleri 1,03±0,16 ve 0,88±0,09 olarak bulundu. 27 (%44,3) hastanın KMY ölçümleri normal sınırlardaydı. Bu hastaların ortalama lomber ve femur KMY değerleri 1,20±0,11 ve 1,11±0,15 olarak bulundu. KMY değerleri normal olan grupla osteopeni olan grup arasında ESH, CRP, ve BASDAI değerleri açısından istatistiksel olarak anlamlı fark bulunmadı (p>0,05). Osteopenisi olan grupta, KMY değerleri ile ESH, CRP, ve BASDAI değerleri arasında bir korelasyon saptanmadı (p>0,05). Sonuç: Çalışmamızda, osteopenisi olan AS’li hastalarda kemik mineral yoğunluğu ile hastalık aktivitesi arasında ilişki bulunmamıştır.
Aim: Ankylosing Spondylitis (AS) is a chronic inflammatory disease. Spinal osteopenia is common in AS, probably due to immobility and local cytokine release. In this study, we evaluated the relationship between bone mineral density and disease activity in Ankylosing Spondylitis patients with osteopenia. Meterial and Methods: Sixty one AS patients (26F, 35M) were enrolled in this study. The disease duration, morning stiffness, Schober tests, Erythrocyte Sedimentation Rate (ESR) and C Reactive Protein (CRP) were analyzed and recorded. Disease activity was evaluated by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Bone mineral density (BMD) was measured by using GE/LUNAR DPX PRO equipment. Results: The mean age and disease duration of the patients were 38.67±10.81 and 7.87±7.09 year. There was osteopenia in 34 (%55.7) patients. Spine and femur BMD values of this patients were 1.03±0.16 and 0.88±0.09. BMD measurements of 27 (%44.3) patient were found normally. Spine and femur BMD values of this patients were 1.20±0.11 and 1.11±0.15. There was not statistically significant difference between osteopenia and normal group in ESR, CRP, and BASDAI values (p>0.05). There was not correlation between BMD values and ESR, CRP, and BASDAI values in osteopenia group (p>0.05). Conclusion: In our study, we did not find relationship between bone mineral density and disease activity in AS patients with osteopenia.
Aim: Ankylosing Spondylitis (AS) is a chronic inflammatory disease. Spinal osteopenia is common in AS, probably due to immobility and local cytokine release. In this study, we evaluated the relationship between bone mineral density and disease activity in Ankylosing Spondylitis patients with osteopenia. Meterial and Methods: Sixty one AS patients (26F, 35M) were enrolled in this study. The disease duration, morning stiffness, Schober tests, Erythrocyte Sedimentation Rate (ESR) and C Reactive Protein (CRP) were analyzed and recorded. Disease activity was evaluated by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Bone mineral density (BMD) was measured by using GE/LUNAR DPX PRO equipment. Results: The mean age and disease duration of the patients were 38.67±10.81 and 7.87±7.09 year. There was osteopenia in 34 (%55.7) patients. Spine and femur BMD values of this patients were 1.03±0.16 and 0.88±0.09. BMD measurements of 27 (%44.3) patient were found normally. Spine and femur BMD values of this patients were 1.20±0.11 and 1.11±0.15. There was not statistically significant difference between osteopenia and normal group in ESR, CRP, and BASDAI values (p>0.05). There was not correlation between BMD values and ESR, CRP, and BASDAI values in osteopenia group (p>0.05). Conclusion: In our study, we did not find relationship between bone mineral density and disease activity in AS patients with osteopenia.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Türk Osteoporoz Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
19
Sayı
2
