The relation between increased carotid intima-media thickness with fibrin monomers in obese children

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dc.contributor.authorYazarli, Esra
dc.contributor.authorUnsal Sac, Rukiye
dc.contributor.authorSimsek, Betul
dc.contributor.authorEngiz, Ozlem
dc.contributor.authorDallar Bilge, Yildiz
dc.contributor.authorAlioglu, Bulent
dc.date.accessioned2024-09-18T21:05:13Z
dc.date.available2024-09-18T21:05:13Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim This study aimed to investigate the association between carotid intima-media changes that play a part in the atherosclerotic process in childhood obesity and fibrin monomers as an important indicator of fibrin plaque. Methods This is a cross-sectional study of obese children and non-obese healthy control subjects. Height, weight, body mass index, waist/hip ratio, systolic/diastolic blood pressures were recorded, in addition, biochemistry, haemogram, fibrin monomers and d-dimer were measured in both groups. Right and left common carotid intima-media thicknesses were measured by ultrasonography and mean carotid intima-media thickness was calculated. Results Obese children (n = 89, 46.1% girls, median age: 12.6 +/- 2.3 years) and healthy control group (n = 40, 52.5% girls, median age: 13.2 +/- 2.2 years) were comparable in terms of gender, age and puberty stage. Mean carotid intima-media thickness was higher in obese children than the healthy control group (P = .002). There was no difference between the two groups in terms of fibrin monomers and d-dimer levels. In obese children, there was a weak negative correlation between mean carotid intima-media thickness and fibrin monomers (P = .030, r = -0.233). Conclusion In obese children, mean carotid intima-media thickness was determined higher, as an early indicator of atherosclerosis. We want to emphasise that obese children are at risk for cardiovascular disease and should be evaluated in terms of atherosclerosis. This study investigates the relation between increased carotid intima-media thickness and fibrin monomers, in children, the first time in Literature.en_US
dc.identifier.doi10.1111/ijcp.14199
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.issue7en_US
dc.identifier.pmid33794044en_US
dc.identifier.scopus2-s2.0-85104254380en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/ijcp.14199
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13458
dc.identifier.volume75en_US
dc.identifier.wosWOS:000639829100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe relation between increased carotid intima-media thickness with fibrin monomers in obese childrenen_US
dc.typeArticleen_US

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