Optical Coherence Tomography Angiography in Schizophrenia

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dc.contributor.authorKokacya, Mehmet Hanifi
dc.contributor.authorCakmak, Ayse Idil
dc.date.accessioned2024-09-18T20:56:52Z
dc.date.available2024-09-18T20:56:52Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: The aim of this study is to investigate the retinovascular structure of schizophrenia patients using optical coherence tomography angiography (OCTA). Methods: 47 eyes of schizophrenia patients were compared with 50 eyes of demographically matched healthy controls in terms of OCTA measurements. Schizophrenia patients were evaluated in two groups as short-term (<= 5years) and long-term (> 5years) according to the time elapsed after the diagnosis of schizophrenia. Results: Schizophrenia patients showed overall thinning of retinal nerve fiber layer and macula, and lower vessel density (VD) compared to controls. The results were significant for thickness measurements of general macula and for VD in specific areas (P <0.05); however, they were not significant for the RNFL measurements except the mean circum-papillary RNFL, which was noted to approach significance (P = 0.055). Long-term patients showed significantly lower VD in the whole and perifoveal region of superficial capillary plexus, the whole, perifoveal and foveal region of deep capillary plexus, and the whole area and the disc of radial peripapillary capillaries compared to short-term patients (P= 0.014, P= 0.009, P=0.011, P= 0.010, P=0.011, P= 0.035, P= 0.030). Conclusions: These findings suggest that schizophrenia may be a neurodegenerative disease with progressive microvascular involvement over the years, and that OCTA has the potential to be a useful tool in detecting retinovascular changes in patients with schizophrenia.en_US
dc.identifier.doi10.5152/alphapsychiatry.2022.21629
dc.identifier.endpage261en_US
dc.identifier.issn2757-8038
dc.identifier.issue5en_US
dc.identifier.pmid36426270en_US
dc.identifier.startpage253en_US
dc.identifier.trdizinid1128173en_US
dc.identifier.urihttps://doi.org/10.5152/alphapsychiatry.2022.21629
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1128173
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12140
dc.identifier.volume23en_US
dc.identifier.wosWOS:000865978900008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofAlpha Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSchizophreniaen_US
dc.subjectneuropathologyen_US
dc.subjectretinal-imagingen_US
dc.subjectretinovascularen_US
dc.titleOptical Coherence Tomography Angiography in Schizophreniaen_US
dc.typeArticleen_US

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