Kardiyak sendrom X'de eritrosit dağılım genişliği (R DW) ile Hs-CRP seviyelerinin incelenmesi
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2013
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info:eu-repo/semantics/openAccess
Özet
Amaç: Kardiyak Sendrom X(KSX), angina pektoris ve objektif iskemi bulgularına rağmen normal koroner arterlerin saptandığı bir tablodur. KSX’ in patogenezinde inflamasyonun rol oynadığı bulunmuştur. Eritrosit dağılım genişliği (RDW), dolaşımdaki eritrositlerin büyüklüğünü gösteren bir indeks olmasının yanında, son çalışmalarda inflamasyonu gösteren bir parametre olarak değerlendirilmeye başlanmıştır. Biz bu çalışmada KSX olan hastalarda inflamasyon ile RDW arasındaki ilişkiyi araştırdık. Yöntem: Bu çalışmaya iskemik bulguların saptandığı koroner anjiyografisi normal olan 35 KSX hastası (KSX grubu), ciddi koroner arter hastalığı bulunan 35 hasta (KAH grubu) ve 34 kontrol hastası alındı. Her üç gruptan RDW ve hs -CRP çalışıldı . Bulgular : KSX grubunda RDW değerleri kontrol grubuna göre artmış bulundu (13.9 ± 1.2 vs 12.9 ±0.7, p < 0.001). Ancak KSX grubu ile KAH grubu arasında fark bulunmadı (13.9 ± 1.2 vs. 14,1 ± 1,1, p: 0. 63). Aynı şekilde KSX ile KAH grubu arasında hs-CRP değerleri arasında fark yoktu(1.03 ± 0.5 vs. 1.05 ± 0.5, p: 0.92). Kontrol grubu nda hs-CRP düzeyi KSX ve KAH grubuna göre anlamlı bir şeki l de düşük bulundu. RDW ile hs- CRP arasında pozitif korelasyon olduğu bulu n du(r=0.24, p: 0.014). Sonuç : RDW, klinikte uzun süredir bilinen ancak inflamatuvar marker olarak yeni kullanılan bir parametre olup KSX olan hasta larda yükselmektedir.
Objective : Cardiac Syndrome X (CSX) is defined as typical chest pain, objective signs of ischemia and normal coronary arteries. The association between CSX and inflammation is well known. Red cell distribution width (RDW), an index of erythrocyte size, is recently found to be associated with inflammation. We investigated the association between RDW and high sensitive C reactive protein (hs-CRP) in patients with CSX. Method : Total 104 patients were included in the study. Those with evidence of ischemia (total of 70) underwent coronary angiography. Patients with a normal coronary angiogram were grouped as the CSX group (n=35 )and those with significant coronary disease were grouped as the coro- nary artery disease(CAD) group(n=35). A total of 34 patients were taken as the control group. RDW and hs-CRP levels were measured. Results : RDW was increased in the CSX group when compared to the Control group (13.9 ± 1.2 vs 12.9 ±0.7, p < 0.001). However, there was no difference between the CSX and CAD groups (13.9 ± 1.2 vs. 14,1 ± 1,1, p: 0. 63). Both groups had higher hs-CRP levels than the Control group. RDW is correlated with hs-CRP (r=0.24, p: 0.014). Conclusion : RDW, a novel inflammatory marker, is eleva ted in CSX and may be promising biomarker in reflecting the inflammatory status in CSX patients.
Objective : Cardiac Syndrome X (CSX) is defined as typical chest pain, objective signs of ischemia and normal coronary arteries. The association between CSX and inflammation is well known. Red cell distribution width (RDW), an index of erythrocyte size, is recently found to be associated with inflammation. We investigated the association between RDW and high sensitive C reactive protein (hs-CRP) in patients with CSX. Method : Total 104 patients were included in the study. Those with evidence of ischemia (total of 70) underwent coronary angiography. Patients with a normal coronary angiogram were grouped as the CSX group (n=35 )and those with significant coronary disease were grouped as the coro- nary artery disease(CAD) group(n=35). A total of 34 patients were taken as the control group. RDW and hs-CRP levels were measured. Results : RDW was increased in the CSX group when compared to the Control group (13.9 ± 1.2 vs 12.9 ±0.7, p < 0.001). However, there was no difference between the CSX and CAD groups (13.9 ± 1.2 vs. 14,1 ± 1,1, p: 0. 63). Both groups had higher hs-CRP levels than the Control group. RDW is correlated with hs-CRP (r=0.24, p: 0.014). Conclusion : RDW, a novel inflammatory marker, is eleva ted in CSX and may be promising biomarker in reflecting the inflammatory status in CSX patients.
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