Investigation of Anti-Inflammatory Effects of Myrtus Communis L. Essential Oil on IL-1? Induced Human Bronchial Epithelial Cell Line: Experimental Study

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dc.authorscopusid23488666100
dc.authorscopusid55963510600
dc.contributor.authorGülbol Duran, Gülay
dc.contributor.authorTerzi, Menderes Yusuf
dc.date.accessioned2024-09-19T15:43:32Z
dc.date.available2024-09-19T15:43:32Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Inflammation is the primary biological response of immune system against infection, injury, and irritation, but when it is not curbed, it can lead to autoimmune and neurodegenerative diseases or cancer. Myrtus communis L. (MC) is an aromatic plant raised in the re-gion of Mediterranean Sea and bearing several pharmacological activities. We aimed in this study to investigate anti-inflammatory effects of MC essential oil that is often utilized by the local population. Material and Methods: Cell culture experiments were conducted with healthy bronchial epithelial lung cell line (BEAS-2B). The cells were grouped in three as follows; non-treated control, interleukin-1 beta (IL-1?) induced inflammatory cells, and MC-treated inflammatory cells. Non-cytotoxic concentrations of MC were determined with MTT assay. The gene expression levels of IL-6, IL-10, inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-?), cyclooxygenase-2 (COX-2), and nuclear factor kappa b (NF?B) were analyzed with reverse transcriptase-quantitative polymerase chain reaction. The protein levels of IL-6, IL-10, iNOS, and TNF-? were detected with ELISA. Results: The elevated mRNA levels of IL-6, IL-10, and NF?B in IL-1?-induced inflammatory cells significantly reduced back to the basal levels after MC treatment. In line with the mRNA levels, the protein levels of IL-6 and IL-10 significantly increased in inflammatory cells. MC treatment reversed this increase in protein levels to the baseline as in the control group. Conclusion: We demonstrated in our study the anti-inflammatory effects of MC essential oil on BEAS-2B cells by inhibiting the expression of pro-inflammatory cytokines. To be able suggest MC essential oil as a potential therapeutic agent with a strong anti-inflammatory action, further studies testing several concentrations are warranted. © 2021 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/medsci.2021-81607
dc.identifier.endpage477en_US
dc.identifier.issn1300-0292
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85123260574en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage470en_US
dc.identifier.trdizinid495890en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2021-81607
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/495890
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14402
dc.identifier.volume41en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectBEAS-2Ben_US
dc.subjectELISAen_US
dc.subjectMyrtus communis L.en_US
dc.subjectRT-qPCRen_US
dc.titleInvestigation of Anti-Inflammatory Effects of Myrtus Communis L. Essential Oil on IL-1? Induced Human Bronchial Epithelial Cell Line: Experimental Studyen_US
dc.title.alternativeMyrtus communis L. Esansiyel Yağının IL-1? ile Uyarılmış İnsan Bronşiyal Epitel Hücre Hattında Antiinflamatuar Etkilerinin Araştırılması: Deneysel Çalışmaen_US
dc.typeArticleen_US

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