Investigation of the protective effect of erdosteine against cyclosporine-induced injury in rat liver with histological and biochemical methods

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dc.contributor.authorNacar, Ahmet
dc.contributor.authorKaraboğa, İhsan
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorKaplan Sefil, Nebihat
dc.contributor.authorNacar, Emel
dc.contributor.authorMotor, Sedat
dc.contributor.authorAkküçük, Seçkin
dc.contributor.authorÖzkan, Orhan Veli
dc.date.accessioned2019-07-16T16:00:25Z
dc.date.available2019-07-16T16:00:25Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground/aim: In the present study, the protective effect of erdosteine against cyclosporine-induced injury in rat liver was investigated with histological and biochemical methods. Materials and methods: Thirty-two Wistar albino male rats were randomly divided into 4 groups: control (n = 8), cyclosporine (n = 8, 20 mg kg–1 day–1 i.p.), cyclosporine + erdosteine (n = 8, erdosteine 12 mg kg–1 day–1 orally), and erdosteine (n = 8). At the end of day 12, liver tissues were removed for histological and biochemical analysis. After liver tissues were fixed in 10% buffered neutral formalin, routine histological processes were applied and tissue sections were stained with hematoxylin and eosin, periodic acid–Schiff, and elastic fiber stain methods. One hundred lobules of liver were examined for each group and evaluated statistically. The levels of malondialdehyde and glutathione peroxidase, as well as the activities of superoxide dismutase, were determined. Results: The cyclosporine group showed significant histopathological changes compared to the control. In the cyclosporine + erdosteine group, histopathological changes of hepatic damage were markedly reduced. Histological findings were supported by biochemical results. Conclusion: Erdosteine could attenuate cyclosporine-induced liver injury.en_US
dc.description.abstractBackground/aim: In the present study, the protective effect of erdosteine against cyclosporine-induced injury in rat liver was investigated with histological and biochemical methods. Materials and methods: Thirty-two Wistar albino male rats were randomly divided into 4 groups: control (n = 8), cyclosporine (n = 8, 20 mg kg–1 day–1 i.p.), cyclosporine + erdosteine (n = 8, erdosteine 12 mg kg–1 day–1 orally), and erdosteine (n = 8). At the end of day 12, liver tissues were removed for histological and biochemical analysis. After liver tissues were fixed in 10% buffered neutral formalin, routine histological processes were applied and tissue sections were stained with hematoxylin and eosin, periodic acid–Schiff, and elastic fiber stain methods. One hundred lobules of liver were examined for each group and evaluated statistically. The levels of malondialdehyde and glutathione peroxidase, as well as the activities of superoxide dismutase, were determined. Results: The cyclosporine group showed significant histopathological changes compared to the control. In the cyclosporine + erdosteine group, histopathological changes of hepatic damage were markedly reduced. Histological findings were supported by biochemical results. Conclusion: Erdosteine could attenuate cyclosporine-induced liver injury.en_US
dc.identifier.endpage1395en_US
dc.identifier.issn1300-0144
dc.identifier.issue6en_US
dc.identifier.pmid26775399en_US
dc.identifier.scopus2-s2.0-84947434789en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1390en_US
dc.identifier.urihttps://trdizin.gov.tr/publication/paper/detail/TVRnMk5UYzBOQT09
dc.identifier.urihttps://hdl.handle.net/20.500.12483/2308
dc.identifier.volume45en_US
dc.identifier.wosWOS:000365510300031en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleInvestigation of the protective effect of erdosteine against cyclosporine-induced injury in rat liver with histological and biochemical methodsen_US
dc.typeArticleen_US

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