Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage

Basit Öğe Kaydı
dc.authoridKoca, Gokhan/0000-0003-2842-9223
dc.authoridAKBULUT, Aylin/0000-0003-4665-7895
dc.contributor.authorYumusak, Nihat
dc.contributor.authorKoca, Gokhan
dc.contributor.authorAkbulut, Aylin
dc.contributor.authorAtilgan, Hasan Ikbal
dc.contributor.authorKorkmaz, Meliha
dc.date.accessioned2024-09-18T19:54:27Z
dc.date.available2024-09-18T19:54:27Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigated anti-proliferative and anti-apoptotic effects of coenzyme Q10 (CoQ10) in the prevention of radioiodine-131 (RAI) (I-1(31)) induced kidney damage. A total of 24 Wistar albino rats were separated into equal three groups (n = 8/group): Group 1 (control): untreated group; Group 2 (RAI): 3 mCi/kg RAI oral route; Group 3 (RAI+CoQ10): 3 mCi/kg RAI oral route and intraperitoneally 30 mg/kg/day CoQ10. CoQ10 treatment was started two days before RAI administration and was continued five days once daily after RAI. Pathomorphological parameters of kidneys were measured using hematoxylin-eosin and Masson's trichrome staining. Immunohistochemically; proliferating cell nuclear antigen (PCNA), caspase 8, caspase 9 and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) were used to determine proliferation and apoptosis. With the exception of the control group, varying degrees of inflammation, degeneration, necrosis, and interstitial/perivascular fibrosis were detected in the kidneys of all rats. This histopathological damage was found to be significantly less in CoQ10 group versus RAI group (P<0.05). The all immunohistochemical examinations demonstrated that administration of CoQ10 had reduced proliferation and apoptosis (P<0.05). The results of kidney histopathology and immunohistochemistry demonstrated that administration of CoQ10 had reduced inflammation, proliferation, and apoptosis. These fmdings show CoQ10 can play an important role in the radioprotection of kidneys against RAI-induced damage.en_US
dc.identifier.doi10.33988/auvfd.871118
dc.identifier.endpage272en_US
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85134064023en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage265en_US
dc.identifier.trdizinid1115384en_US
dc.identifier.urihttps://doi.org/10.33988/auvfd.871118
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1115384
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7746
dc.identifier.volume69en_US
dc.identifier.wosWOS:000827878500004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAnkara Univ Pressen_US
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntiapoptoticen_US
dc.subjectantiproliferativeen_US
dc.subjectcoenzyme Q10en_US
dc.subjectkidneyen_US
dc.subjectradioiodine-131en_US
dc.titleProliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damageen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
7746.pdf
Boyut:
6.13 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu