Enantioselective conjugate addition of pyrazolones to nitroalkenes catalyzed by chiral squaramide organocatalyst
Yükleniyor...
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The chiral squaramide catalysts (8-15) were synthesized, and their catalytic efficiency in the enantioselective conjugate addition of pyrazolones to nitroalkenes was described. This protocol provides excellent chemical yields (up to 93%) of chiral 5-methyl-4-(2-nitro-1-arylethyl)pyrazol-3-ol derivatives with high enantioselectivities (up to 97% ee).
Açıklama
Anahtar Kelimeler
chiral squaramide catalysts, enantioselective synthesis, Michael addition, pyrazolones
Kaynak
Chirality
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
33
Sayı
3
