Expression Patterns of Some Lipogenic Genes and Fatty Acid Profile of Liver in Food-Restricted Rats

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dc.contributor.authorÖzkan, Hüseyin
dc.contributor.authorKaraaslan, İrem
dc.contributor.authorKaya, Ufuk
dc.contributor.authorDalkıran, Sevda
dc.contributor.authorAlakuş, İbrahim
dc.contributor.authorÇamdeviren, Baran
dc.contributor.authorKeçeli, Hasan Hüseyin
dc.date.accessioned2024-09-19T16:23:30Z
dc.date.available2024-09-19T16:23:30Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study aimed to determine food restriction effects on the profile of fatty acids and major genes on lipogenesis expressions in liver. 16 Wistar albino rats were divided into two groups and different diets were given to groups for 4-weeks. First group was fed ad libitum (Control group), another group was fed the half amount of the daily requirement (Food Restriction group, FR). As well as weekly food consumption and body weight changes, total cholesterol, HDL, LDL, and triglyceride levels were determined at the end of the feeding period. In addition to the fatty acid profile, FASN and SCD-1 genes expression levels were measured in the liver. While the body weight averages decreased after 7 days and remained similar, plasma glucose levels were found lower in the FR. FASN was upregulated approximately 6 folds, and SCD-1 increased insignificantly about 3 folds in the FR. C15:0, C18:1 n9 trans, C18:2 n6 cis, C21:0, C20:2, C20:5 n3, n6 and UFA were lower, while C16:0, C18:2 n6 trans, C20:3 n6, C22:6 n3, C22:1 n9, C22:2 and SFA were higher in FR. In addition to considering the exposure time and rate of food restriction, molecular activity and interactions in other metabolic organs should be investigated.en_US
dc.identifier.doi10.30607/kvj.1173180
dc.identifier.endpage142en_US
dc.identifier.issn1308-1594
dc.identifier.issn2147-6853
dc.identifier.issue2en_US
dc.identifier.startpage131en_US
dc.identifier.trdizinid1188050en_US
dc.identifier.urihttps://doi.org/10.30607/kvj.1173180
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1188050
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15926
dc.identifier.volume16en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofKocatepe Veterinary Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFatty acidsen_US
dc.subjectfood restrictionen_US
dc.subjectliveren_US
dc.subjectFASNen_US
dc.subjectSCD-1en_US
dc.titleExpression Patterns of Some Lipogenic Genes and Fatty Acid Profile of Liver in Food-Restricted Ratsen_US
dc.typeArticleen_US

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