Parvoviral enteritisli köpeklerde bazı kardiyak biyobelirteçlerin araştırılması
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Tarih
2022
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Hatay Mustafa Kemal Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Köpek parvoviral enteritli (CPV) genç yavrularda miyokarditin saptanması için biyobelirteçler üzerine araştırmalar halen devam etmektedir. Bu çalışmanın amacı, parvoviral enteritte (PVE) EKG, CK-MB, CT-1 ve Gal-3 gibi seçilmiş bazı kardiyak biyobelirteçlerdeki değişiklikleri ortaya koyarak hastalığın enterit formunda miyokardit varlığını belirlemekti. Çalışmanın materyalini 33 parvoviral enteritis (deney grubu) ve 8 sağlıklı aşı programı tamamlanmış 1yaş altı köpek (kontrol grubu) oluşturmuştur. Parvoviral enteritisli köpeklerde anoreksi, ateş, depresyon, kusma ve kanlı/kansız ishal tespit edilmiştir. Teşhis, dışkıda köpek parvovirus antijenini tespit eden hızlı tanı test kiti ile doğrulandı. Tüm köpeklerden kan örnekleri ve EKG kayıtları alındı. Parvoviral enteritisli köpeklere standart tedavi uygulandı. Tüm PVE köpeklerin serum kretin kinaz (CK), kretin kinaz-MB (CK-MB), galaktin-3 (Gal-3) ve kardiyotrofin-1 (CT-1) seviyeleri kontrol grubuna göre daha yüksekti p<0,05. Toplam lökosit sayısı tüm PVE grubunda düşük ve anlamlıydı. 3 aylıktan küçük köpeklerde HGB ve HCT değerleri kontrol grubu ile benzer olmasına rağmen referans limitlerin altında, RDW% ise diğer üç gruba göre daha yüksekti. Kreatinin tüm PVE gruplarında önemli ölçüde azaldı. 3 aylıktan küçük PVE köpeklerinde sinüs taşikardisi tespit edildi. EKG bulgularında kısa QT ve PR intervali <3 aylık PVE grubunda anlamlıydı. Sonuç olarak, EKG değişiklikleri, özellikle <3 aylık PVE köpeklerde miyokard hasarının belirlenmesinde daha belirleyicidir. PVE köpeklerde CK-MB ve CK ile paralel olarak artan Gal-3 ve özellikle CT-1, miyokardiyal hasar ve inflamasyonu ortaya koymada yeni biyobelirteçler olarak değerlendirilebilir. Ancak enteritli miyokardit olgularını ortaya çıkarmak için postmortem incelemeleri olan daha detaylı klinik çalışmalara ihtiyaç vardır.
The Investigation of Some Cardiac Bıomarkers in Dogs With Parvoviral Enteritis The research on biomarkers for detecting myocarditis in young puppy with canine parvoviral enteritis (CPV) is still ongoing. The aim of this study was to determine the presence of myocarditis in the enteritis form of the disease by revealing the changes in ECG and some selected cardiac biomarkers such as CK-MB, CT-1 and Gal-3 in parvoviral enteritis (PVE). The material of the study consisted of 33 parvoviral enteritis (experimental group) and 8 healthy dogs, under one year old and completed vaccination program (control group). Anorexia, fever, depression, vomiting and bloody/nonbloody diarrhea were detected in dogs with parvoviral enteritis. The diagnosis was confirmed by rapid tests, detecting canine parvovirus antigen in stool. Blood samples and ECG recordings were obtainet from all dogs. Standard treatment was applied to dogs with parvoviral enteritis. Serum craetin kinase (CK), creatin kinase-MB (CK-MB), galactin-3 (Gal-3) and cardiotrophin I (CT-1) levels of all PVE dogs were higher and significant than the control group. Total leukocyte count was low and significant in all PVE group. Although HBG and HCT values were similar to the control group in dogs less than 3 months old, they were below the reference limits, and RDW% was higher than the other three groups. Creatinine decreased significantly in all PVE groups. Sinus tachycardia was detected in PVE dogs younger than 3 months of age. In ECG findings, short QT and PR interval were viewed significant in <3 month of age PVE group. As a result, ECG changes are more determinant in the determination of myocardial damage, especially in PVE dogs <3 months old. Gal-3 and especially CT-1, which increase in parallel to CK-MB and CK in PVE dogs, can be evaluated as new biomarkers for to revealet vrevealing myocardial damage and inflammation. however, more detailed clinical studies with postmortem examinations should be proven to reveal myocarditis cases with enteritis.
The Investigation of Some Cardiac Bıomarkers in Dogs With Parvoviral Enteritis The research on biomarkers for detecting myocarditis in young puppy with canine parvoviral enteritis (CPV) is still ongoing. The aim of this study was to determine the presence of myocarditis in the enteritis form of the disease by revealing the changes in ECG and some selected cardiac biomarkers such as CK-MB, CT-1 and Gal-3 in parvoviral enteritis (PVE). The material of the study consisted of 33 parvoviral enteritis (experimental group) and 8 healthy dogs, under one year old and completed vaccination program (control group). Anorexia, fever, depression, vomiting and bloody/nonbloody diarrhea were detected in dogs with parvoviral enteritis. The diagnosis was confirmed by rapid tests, detecting canine parvovirus antigen in stool. Blood samples and ECG recordings were obtainet from all dogs. Standard treatment was applied to dogs with parvoviral enteritis. Serum craetin kinase (CK), creatin kinase-MB (CK-MB), galactin-3 (Gal-3) and cardiotrophin I (CT-1) levels of all PVE dogs were higher and significant than the control group. Total leukocyte count was low and significant in all PVE group. Although HBG and HCT values were similar to the control group in dogs less than 3 months old, they were below the reference limits, and RDW% was higher than the other three groups. Creatinine decreased significantly in all PVE groups. Sinus tachycardia was detected in PVE dogs younger than 3 months of age. In ECG findings, short QT and PR interval were viewed significant in <3 month of age PVE group. As a result, ECG changes are more determinant in the determination of myocardial damage, especially in PVE dogs <3 months old. Gal-3 and especially CT-1, which increase in parallel to CK-MB and CK in PVE dogs, can be evaluated as new biomarkers for to revealet vrevealing myocardial damage and inflammation. however, more detailed clinical studies with postmortem examinations should be proven to reveal myocarditis cases with enteritis.
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Anahtar Kelimeler
Veteriner Hekimliği, Veterinary Medicine, Köpek, Parvoviral enteritis, miyokardit, galaktin-3, kardiyotrofin-1, Dog, Parvoviral enteritis, myocarditis, galectine-3, cardiotrophine-1
