New genetic risk factors for myocardial infarction at young patients in Southern Turkey

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dc.authoridcagliyan, caglar/0000-0002-2529-4995
dc.contributor.authorAkilli, Rabia Eker
dc.contributor.authorCagliyan, Caglar Emre
dc.contributor.authorKaypakli, Onur
dc.contributor.authorKanadasi, Mehmet
dc.contributor.authorDemirtas, Mustafa
dc.date.accessioned2024-09-18T20:33:03Z
dc.date.available2024-09-18T20:33:03Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: Genetic predisposition plays an important role in the development of atherosclerosis in young patients. The aim of this study was to determine the relationship between myocardial infarction and HLA antigens in young patients who had myocardial infarction in southern region of Turkey. Materials and Methods: We enrolled 50 patients (36 male, 14 female, mean age 45.0 +/- 7.1) who had myocardial infarction before 45 years old in men and 55 years old in women and 50 healthy subjects (31 male, 19 female, mean age 51.5 +/- 5.5) as a control group into the study. Venous blood samples were collected for HLA tissue typing and determining trombogenic factors. Histocompatibility antigens (HLA-A,B,C,-DQ,-DR) were studied with Polymerase Chain Reaction (PCR)-Sequance Spesific Oligonucleotide typing (SSO) method. Results: Frequency of HLA antigens in patients and controls were 38% and 10% for HLA-A24, 40% and 10% for HLA-DQB2, 26% and 6% for HLA-DRB1-7 and 52% and 26% for HLA-DRB4-1. Chi square test revealed a significant relation with the disease and the presence of these antigens. In the logistic regression analysis, smoking, Lp(a), homocysteine and HLA-DQB1 subtype were independently associated with development of MI in young patients. Conclusion: The presence of HLA-A24, HLA-DQB2, HLA-DRB1-7 and HLA-DRB4-1 may be used as genetic markers for the tendency to coronary artery disease in southern region of Turkey.en_US
dc.identifier.doi10.17826/cumj.623510
dc.identifier.endpage8en_US
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.trdizinid384414en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.623510
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/384414
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11280
dc.identifier.volume45en_US
dc.identifier.wosWOS:000522558800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMyocardial infarctionen_US
dc.subjectgenetic risk factorsen_US
dc.subjectHLA antigensen_US
dc.titleNew genetic risk factors for myocardial infarction at young patients in Southern Turkeyen_US
dc.typeArticleen_US

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