Effects of platelet-rich plasma on cartilage regeneration after costal cartilage resection: a stereological and histopathological study
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Dosyalar
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Acta Medical Belgica
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: In cases of congenital chest wall deformities, it is important to maintain the flexibility of the chest wall after rib cartilage resection. In this study, we aimed to determine the regeneration capability of cartilage and the effects of platelet-rich plasma (PRP) on the regeneration process. Methods: A total of 16 four-week-old New Zealand rabbits were used in this study. In the 4th-5th right costal cartilages, the perichondrial sheaths were dissected and costal cartilages were excised. Then, the perichondrial sheaths were closed with absorbable material in the sham group (n = 8), and this was done after replacing PRP in the PRP group (n = 8). The left costal cartilages of the animals were used as controls. The volumes of the costal cartilages and their perichondrial sheaths were estimated using Cavalieri's principle. In addition, the mean numerical densities of the chondroblasts and chondrocytes per square millimetre were estimated using unbiased counting frames. Results: In the PRP and sham groups, the volumes of the cartilages and perichondrial sheaths were higher than those of the control group (p<0.05). The numerical densities of the chondroblasts and chondrocytes increased more in the PRP group than in the sham group (p<0.05). Conclusions: Applying PRP after resection may provide better healing and faster regeneration of cartilage.
Açıklama
Anahtar Kelimeler
Pectus deformities, Cavalieri's principle, plateletrich plasma, costal cartilage, stereology
Kaynak
Acta Chirurgica Belgica
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
117
Sayı
1
