Effects of platelet-rich plasma on cartilage regeneration after costal cartilage resection: a stereological and histopathological study

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dc.contributor.authorSengul, Aysen Taslak
dc.contributor.authorBuyukkkarabacak, Yasemin Bilgin
dc.contributor.authorAltunkaynak, Berrin Zuhal
dc.contributor.authorYetim, Tulin Durgun
dc.contributor.authorAltun, Gamze Yayla
dc.contributor.authorSengul, Bilal
dc.contributor.authorBasoglu, Ahmet
dc.date.accessioned2024-09-18T20:54:08Z
dc.date.available2024-09-18T20:54:08Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: In cases of congenital chest wall deformities, it is important to maintain the flexibility of the chest wall after rib cartilage resection. In this study, we aimed to determine the regeneration capability of cartilage and the effects of platelet-rich plasma (PRP) on the regeneration process. Methods: A total of 16 four-week-old New Zealand rabbits were used in this study. In the 4th-5th right costal cartilages, the perichondrial sheaths were dissected and costal cartilages were excised. Then, the perichondrial sheaths were closed with absorbable material in the sham group (n = 8), and this was done after replacing PRP in the PRP group (n = 8). The left costal cartilages of the animals were used as controls. The volumes of the costal cartilages and their perichondrial sheaths were estimated using Cavalieri's principle. In addition, the mean numerical densities of the chondroblasts and chondrocytes per square millimetre were estimated using unbiased counting frames. Results: In the PRP and sham groups, the volumes of the cartilages and perichondrial sheaths were higher than those of the control group (p<0.05). The numerical densities of the chondroblasts and chondrocytes increased more in the PRP group than in the sham group (p<0.05). Conclusions: Applying PRP after resection may provide better healing and faster regeneration of cartilage.en_US
dc.identifier.doi10.1080/00015458.2016.1210874
dc.identifier.endpage28en_US
dc.identifier.issn0001-5458
dc.identifier.issue1en_US
dc.identifier.pmid27487267en_US
dc.identifier.scopus2-s2.0-85015583568en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.1080/00015458.2016.1210874
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11606
dc.identifier.volume117en_US
dc.identifier.wosWOS:000396648800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Medical Belgicaen_US
dc.relation.ispartofActa Chirurgica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPectus deformitiesen_US
dc.subjectCavalieri's principleen_US
dc.subjectplateletrich plasmaen_US
dc.subjectcostal cartilageen_US
dc.subjectstereologyen_US
dc.titleEffects of platelet-rich plasma on cartilage regeneration after costal cartilage resection: a stereological and histopathological studyen_US
dc.typeArticleen_US

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