Synthesis and evaluation of antimicrobial activity of some 1,5(6)-H/or -methyl-2-subtituted benzimidazole derivatives
[ N/A ]
Tarih
2007
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Chemical Publishing Co.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, the investigation of structure-activitiy relationships for some newly synthesized benzimidazole structures was aimed. For this purpose, eight compounds having 1,5(6)-H/or -CH3 and 2-substituted benzimidazole structures were synthesized. Subsequently, their antimicrobial activities were examined. These compounds were tested in vitro against three Gram positive (Enterococcus faecalis, Staphylocccus aureus and Staphylocccus epidermidis) and two Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa). In addition, they were screened in vitro for their antifungal activities. All of these compounds inhibited the growth of Gram positive and Gram negative bacteria at MIC values between 12.5 and 200 ?g/mL and had MIC values between 50 and 200 ?g/mL for the following fungi (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis and Candida parapsilosis).
Açıklama
Anahtar Kelimeler
Antibacterial and antifungal activity, Antimicrobial, Benzimidazole
Kaynak
Asian Journal of Chemistry
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
19
Sayı
4
