Synthesis and evaluation of antimicrobial activity of some 1,5(6)-H/or -methyl-2-subtituted benzimidazole derivatives

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dc.authorscopusid6507133577
dc.authorscopusid35612683100
dc.authorscopusid25229627300
dc.contributor.authorAlgul, Oztekin
dc.contributor.authorDuran, Nizami
dc.contributor.authorGulbo, Gulay
dc.date.accessioned2024-09-19T15:43:31Z
dc.date.available2024-09-19T15:43:31Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn this study, the investigation of structure-activitiy relationships for some newly synthesized benzimidazole structures was aimed. For this purpose, eight compounds having 1,5(6)-H/or -CH3 and 2-substituted benzimidazole structures were synthesized. Subsequently, their antimicrobial activities were examined. These compounds were tested in vitro against three Gram positive (Enterococcus faecalis, Staphylocccus aureus and Staphylocccus epidermidis) and two Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa). In addition, they were screened in vitro for their antifungal activities. All of these compounds inhibited the growth of Gram positive and Gram negative bacteria at MIC values between 12.5 and 200 ?g/mL and had MIC values between 50 and 200 ?g/mL for the following fungi (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis and Candida parapsilosis).en_US
dc.identifier.endpage3092en_US
dc.identifier.issn0970-7077
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-37049029957en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage3085en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14386
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherChemical Publishing Co.en_US
dc.relation.ispartofAsian Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial and antifungal activityen_US
dc.subjectAntimicrobialen_US
dc.subjectBenzimidazoleen_US
dc.titleSynthesis and evaluation of antimicrobial activity of some 1,5(6)-H/or -methyl-2-subtituted benzimidazole derivativesen_US
dc.typeArticleen_US

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