The effect of menopause on the relationship between hyperlipidemia and periodontal disease via salivary 8-hydroxy-2?-deoxyguanosine and myeloperoxidase levels
Yükleniyor...
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Impairment of the lipid metabolism could affect the periodontal disease; increased oxidative stress may have a role in this relationship. The aim of the present study was to evaluate the role of menopause in the relationship between hyperlipidemia and periodontal disease via oxidative stress markers in saliva. Materials and methods: Sixty-seven women were enrolled in the study and divided into four groups as systemically healthy and premenopause (C) (n=18), hyperlipidemia and premenopause (H) (n=16), systemically healthy and postmenopause (M) (n=17), and hyperlipidemia and postmenopause (MH) (n=16). Sociodemographics, periodontal and metabolic parameters, and saliva oxidative markers (myeloperoxidase [MPO] and 8-hydroxy-2-deoxyguanosine [8-OHdG]) were evaluated. Results: Menopause and/or hyperlipidemia were associated with an increase in all evaluated periodontal parameters. Saliva 8-OHdG and MPO levels were higher in menopausal groups (M and MH). Multivariate linear regression analyses revealed that hyperlipidemia was related to an increase in periodontal parameters. Salivary oxidative stress markers and periodontal parameters were also positively associated with menopause and hyperlipidemia. Conclusion: Saliva 8-OHdG and MPO levels may indicate that the relationship between periodontal disease and hyperlipidemia is aggravated by menopause.
Açıklama
Anahtar Kelimeler
periodontal disease, menopause, hyperlipidemia, oxidative stress, saliva
Kaynak
Acta Odontologica Scandinavica
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
76
Sayı
2
