The effect of menopause on the relationship between hyperlipidemia and periodontal disease via salivary 8-hydroxy-2?-deoxyguanosine and myeloperoxidase levels

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dc.contributor.authorDogan, Esra Sinem Kemer
dc.contributor.authorKirzioglu, Fatma Yesim
dc.contributor.authorDogan, Burak
dc.contributor.authorFentoglu, Ozlem
dc.contributor.authorKale, Banu
dc.date.accessioned2024-09-18T20:54:10Z
dc.date.available2024-09-18T20:54:10Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Impairment of the lipid metabolism could affect the periodontal disease; increased oxidative stress may have a role in this relationship. The aim of the present study was to evaluate the role of menopause in the relationship between hyperlipidemia and periodontal disease via oxidative stress markers in saliva. Materials and methods: Sixty-seven women were enrolled in the study and divided into four groups as systemically healthy and premenopause (C) (n=18), hyperlipidemia and premenopause (H) (n=16), systemically healthy and postmenopause (M) (n=17), and hyperlipidemia and postmenopause (MH) (n=16). Sociodemographics, periodontal and metabolic parameters, and saliva oxidative markers (myeloperoxidase [MPO] and 8-hydroxy-2-deoxyguanosine [8-OHdG]) were evaluated. Results: Menopause and/or hyperlipidemia were associated with an increase in all evaluated periodontal parameters. Saliva 8-OHdG and MPO levels were higher in menopausal groups (M and MH). Multivariate linear regression analyses revealed that hyperlipidemia was related to an increase in periodontal parameters. Salivary oxidative stress markers and periodontal parameters were also positively associated with menopause and hyperlipidemia. Conclusion: Saliva 8-OHdG and MPO levels may indicate that the relationship between periodontal disease and hyperlipidemia is aggravated by menopause.en_US
dc.identifier.doi10.1080/00016357.2017.1386798
dc.identifier.endpage97en_US
dc.identifier.issn0001-6357
dc.identifier.issn1502-3850
dc.identifier.issue2en_US
dc.identifier.pmid28984174en_US
dc.identifier.scopus2-s2.0-85030704483en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage92en_US
dc.identifier.urihttps://doi.org/10.1080/00016357.2017.1386798
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11640
dc.identifier.volume76en_US
dc.identifier.wosWOS:000423472700003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Odontologica Scandinavicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectperiodontal diseaseen_US
dc.subjectmenopauseen_US
dc.subjecthyperlipidemiaen_US
dc.subjectoxidative stressen_US
dc.subjectsalivaen_US
dc.titleThe effect of menopause on the relationship between hyperlipidemia and periodontal disease via salivary 8-hydroxy-2?-deoxyguanosine and myeloperoxidase levelsen_US
dc.typeArticleen_US

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