Rutin Attenuates Methotrexate-Induced Hepatic Oxidative Stress in Rats

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dc.contributor.authorTürk, Sueda
dc.contributor.authorKazak, Filiz
dc.contributor.authorCoşkun, Pınar
dc.contributor.authorKısaçam, Mehmet Ali
dc.date.accessioned2024-09-19T16:21:04Z
dc.date.available2024-09-19T16:21:04Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study aimed to assess the antioxidant effects of rutin on methotrexate-induced hepatic oxidative stress. Wistar Albino rats (n=24) were separated into 4 groups: control group (C); methotrexate (M, 20 mg/kg, single dose) group; rutin (R, 50 mg/kg/day, for fifteen days) group; and methotrexate + rutin [MR, methotrexate (20 mg/kg, single dose) + rutin (50 mg/kg/day, for fifteen days)] group. Rats were sacrificed on the sixteenth day and liver tissues were removed. The liver glucose-6-phosphate dehydrogenase (G6PD), glutathione peroxidase (GPx), malondialdehyde (MDA), nicotinamide adenine dinucleotide phosphate (NADPH), total glutathione (tGSH), and vitamin C were determined colorimetrically. Malondialdehyde increased and vitamin C decreased in the M group compared to the others (P<0.001). Total glutathione reduced in both M and MR groups compared to C group (P<0.05). An important decrease in M group NADPH and GPx compared to C group (P<0.001) was observed. Nicotinamide adenine dinucleotide phosphate of R group were determined to be higher than M group (P<0.001). In this study, it might demonstrate that methotrexate caused oxidative stress in the liver and rutin had antioxidant effects on methotrexate-induced hepatic oxidative stress. Consequently, it can be suggested that rutin may be useful in attenuating the side effects of methotrexate on the liver.en_US
dc.identifier.doi10.17094/ataunivbd.982438
dc.identifier.endpage297en_US
dc.identifier.issn1306-6137
dc.identifier.issue3en_US
dc.identifier.startpage291en_US
dc.identifier.trdizinid503380en_US
dc.identifier.urihttps://doi.org/10.17094/ataunivbd.982438
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/503380
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15580
dc.identifier.volume16en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAtatürk Üniversitesi Veteriner Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLiveren_US
dc.subjectMethotrexateen_US
dc.subjectNicotinamide adenine dinucleotide phosphateen_US
dc.subjectRutinen_US
dc.titleRutin Attenuates Methotrexate-Induced Hepatic Oxidative Stress in Ratsen_US
dc.typeArticleen_US

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