The Use of Plasma-Derived Factor VIII in Two Patients Diagnosed with TTP

Basit Öğe Kaydı
dc.authoridILHAN, GUL/0000-0003-1616-6358
dc.authoridKaya, Mehmet Nur/0000-0003-4368-3078
dc.contributor.authorKaya, Mehmet Nur
dc.contributor.authorIlhan, Gul
dc.contributor.authorKaya, Hasan
dc.date.accessioned2024-09-18T21:00:24Z
dc.date.available2024-09-18T21:00:24Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThrombotic thrombocytopenic purpura (TTP) develops due to increased von Willebrand factor multimers as a result of a deficiency of the a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 enzyme. It has two forms; acquired or congenital (hereditary and familial). The initial clinical manifestations of this disease have been defined as a pentad consisting of thrombocytopenia, microangiopathic hemolytic anemia, neurological findings, acute renal failure, and fever. The basis of TTP therapy consists of fresh frozen plasma (FFP) and therapeutic plasma exchange (TPE). Our cases were two patients diagnosed with congenital TTP. Plasma-derived factor 8, which is a Factor VIII concentrate, was administered to these patients at a dose of 30 U/kg/week due to the allergic reactions the patients developed during their FFP and TPE treatments, prevention of exposure to the viral agent and ineffective treatment. After this treatment, laboratory parameters improved in case 1 and clinical improvement was achieved. In case 2, however, the desired level of laboratory parameters could not be reached and no clinical improvement was achieved.en_US
dc.identifier.doi10.4274/cjms.2021.3568
dc.identifier.endpage814en_US
dc.identifier.issn2149-7893
dc.identifier.issn2536-507X
dc.identifier.issue6en_US
dc.identifier.startpage812en_US
dc.identifier.trdizinid1170480en_US
dc.identifier.urihttps://doi.org/10.4274/cjms.2021.3568
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1170480
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12660
dc.identifier.volume7en_US
dc.identifier.wosWOS:000919559700017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofCyprus Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTTPen_US
dc.subjectplasma -derived factor VIIIen_US
dc.subjectADAMTS-13en_US
dc.titleThe Use of Plasma-Derived Factor VIII in Two Patients Diagnosed with TTPen_US
dc.typeArticleen_US

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