SYNERGISTIC EFFICACY OF EUCALYPTOL WITH ACYCLOVIR AGAINST HSV-2
Yükleniyor...
Dosyalar
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Inst. Nat. Cercetare-Dezvoltare Text. Pielarie
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The increasing drug resistance in herpes viruses in recent years brings with it new treatment approaches. In recent years, it has been tried to overcome drug resistance, especially with the use of herbal products in combination with existing drugs. In this study, we aimed to investigate the effectiveness of eucalyptol in combination with acyclovir. A Vero cell line was used for toxicity tests and viral culture isolation studies in the study. The non-toxic concentrations of eucalyptol and acyclovir were determined by the MTT method. Antiviral efficacy studies were performed within non-toxic concentrations. Antiviral activity was determined by calculating the IC50 values of the compounds against HSV-2. In addition, it was evaluated by the RT-PCR method. The 50% inhibitory concentration (IC50) and Fractional inhibitory concentration (FIC) index values determined during 24 hours and 48 hours of action showed that Eucalyptol exhibited a potent activity. This efficacy was found to be stronger when used in combination with acyclovir. These results show that the combination of Eucalyptol and acyclovir may be beneficial against resistant HSV infections. We suggest that the results of these studies, which are planned as in-vitro, be supported by in-vivo studies. © 2022 Toate drepturile asupra acestei edi?ii sunt rezervate editorilor.
Açıklama
9th International Conference on Advanced Materials and Systems, ICAMS 2022 -- 26 October 2022 through 28 October 2022 -- Bucharest -- 292469
Anahtar Kelimeler
acyclovir, antiviral, Eucalyptol, HSV-2, synergy
Kaynak
ICAMS Proceedings of the International Conference on Advanced Materials and Systems
WoS Q Değeri
Scopus Q Değeri
N/A
