SYNERGISTIC EFFICACY OF EUCALYPTOL WITH ACYCLOVIR AGAINST HSV-2

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dc.authorscopusid57196342765
dc.authorscopusid35612683100
dc.contributor.authorAy, Emrah
dc.contributor.authorDuran, Nizami
dc.date.accessioned2024-09-19T15:41:16Z
dc.date.available2024-09-19T15:41:16Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description9th International Conference on Advanced Materials and Systems, ICAMS 2022 -- 26 October 2022 through 28 October 2022 -- Bucharest -- 292469en_US
dc.description.abstractThe increasing drug resistance in herpes viruses in recent years brings with it new treatment approaches. In recent years, it has been tried to overcome drug resistance, especially with the use of herbal products in combination with existing drugs. In this study, we aimed to investigate the effectiveness of eucalyptol in combination with acyclovir. A Vero cell line was used for toxicity tests and viral culture isolation studies in the study. The non-toxic concentrations of eucalyptol and acyclovir were determined by the MTT method. Antiviral efficacy studies were performed within non-toxic concentrations. Antiviral activity was determined by calculating the IC50 values of the compounds against HSV-2. In addition, it was evaluated by the RT-PCR method. The 50% inhibitory concentration (IC50) and Fractional inhibitory concentration (FIC) index values determined during 24 hours and 48 hours of action showed that Eucalyptol exhibited a potent activity. This efficacy was found to be stronger when used in combination with acyclovir. These results show that the combination of Eucalyptol and acyclovir may be beneficial against resistant HSV infections. We suggest that the results of these studies, which are planned as in-vitro, be supported by in-vivo studies. © 2022 Toate drepturile asupra acestei edi?ii sunt rezervate editorilor.en_US
dc.identifier.doi10.24264/icams-2022.III.3
dc.identifier.endpage278en_US
dc.identifier.issn2068-0783
dc.identifier.scopus2-s2.0-85153533856en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage273en_US
dc.identifier.urihttps://doi.org/10.24264/icams-2022.III.3
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14146
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInst. Nat. Cercetare-Dezvoltare Text. Pielarieen_US
dc.relation.ispartofICAMS Proceedings of the International Conference on Advanced Materials and Systemsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacycloviren_US
dc.subjectantiviralen_US
dc.subjectEucalyptolen_US
dc.subjectHSV-2en_US
dc.subjectsynergyen_US
dc.titleSYNERGISTIC EFFICACY OF EUCALYPTOL WITH ACYCLOVIR AGAINST HSV-2en_US
dc.typeConference Objecten_US

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