Investigation of neuroprotective and therapeutic effects of hesperidin in experimental spinal cord ınjury

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dc.authorid0000-0001-6080-1860en_US
dc.authorid0000-0003-3896-9944en_US
dc.authorid0000-0003-1320-0709en_US
dc.authorid0000-0002-8614-3971en_US
dc.authorid0000-0001-6791-1595en_US
dc.contributor.authorYurtal, Ziya
dc.contributor.authorAltuğ, Enes Muhammed
dc.contributor.authorUnsaldı, Emine
dc.contributor.authorSecıntı, Evrim İlke
dc.contributor.authorKucukgul, Altug
dc.date.accessioned2022-11-25T11:50:53Z
dc.date.available2022-11-25T11:50:53Z
dc.date.issued2020en_US
dc.departmentVeteriner Fakültesien_US
dc.description.abstractTo investigate the neuroprotective and therapeutic efficacy of hesperidin against secondary damage following traumatic spinal cord injury. MATERIAL and METHODS: A total of 32 male Wistar albino rats weighing 250–300 g were randomly divided into four groups (n=4): group I, control group; group II, sham group; group III, preconditioning group, and group IV, treatment group. A rat model of spinal cord injury was established by dropping a weight of 100 g/cm on the spinal cord exposed at T7–T10 with dorsal laminectomy. In neurological examination after the trial period, inclined planed test, modified Tarlov scale, and finger extension test were performed. Furthermore, the bioefficacy of hesperidin was investigated histopathologically, biochemically, and immunohistochemically using blood and tissue samples obtained from the experimental animals.RESULTS: Neurological examination following spinal cord injury revealed that hesperidin significantly contributed to improvement in the 24-hour period. Biochemical analyses revealed that hesperidin showed anti-inflammatory effects by decreasing IL-1β and TNF-α levels at the 24th hour as well as strong antioxidant activity by increasing TAS levels in groups III and IV. Histopathologically, hesperidin reduced hemorrhage, laceration, axonal and neuronal degeneration, necrosis, inflammatory reaction, and edema in groups III and IV. Immunohistochemically, hesperidin reduced the number of caspase 3-positive apoptotic cells in groups III and IV.CONCLUSION: Hesperidin showed antioxidant, anti-inflammatory, and anti-apoptotic effects during the acute period following spinal cord injury; thus, hesperidin shows neuroprotective and therapeutic efficacy in spinal cord injury.en_US
dc.identifier.citationYURTAL Z, ALTUĞ M, ÜNSALDI E, SEÇİNTİ İ, KUCUKGUL A (2020). Investigation of Neuroprotective and Therapeutic Effects of Hesperidin in Experimental Spinal Cord Injury. Turkish Neurosurgery, 30(6), 899 - 906. 10.5137/1019-5149.JTN.29611-20.2en_US
dc.identifier.doi10.5137/1019-5149.JTN.29611-20.2en_US
dc.identifier.endpage906en_US
dc.identifier.issn1019-5149
dc.identifier.issue6en_US
dc.identifier.pmid33216334en_US
dc.identifier.scopus2-s2.0-85098932918en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage899en_US
dc.identifier.trdizinid409790en_US
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.29611-20.2
dc.identifier.urihttps://hdl.handle.net/20.500.12483/3403
dc.identifier.volume30en_US
dc.identifier.wosWOS:000593272300015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherBuluş Tasarım ve Matbaacılık Hizmetlerien_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSpinal cord injuryen_US
dc.subjectHesperidinen_US
dc.subjectOxidative stressen_US
dc.subjectApoptosisen_US
dc.subjectCaspase-3en_US
dc.subjectRatsen_US
dc.titleInvestigation of neuroprotective and therapeutic effects of hesperidin in experimental spinal cord ınjuryen_US
dc.typeArticleen_US

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