Effect of levetiracetam on penicillin induced epileptic activity in rats
Yükleniyor...
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nencki Inst Experimental Biology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of this study was to investigate the effects of levetiracetam (LEV) on penicillin- induced epileptiform activity in rats. Penicillin was applied intracerebroventricularly (icy) at a dose of 500 IU to induce epileptiform activity. LEV was given intraperitoneally (ip) at doses of 20, 40, 80 mg/kg before penicillin injection. This agent reduced epileptiform activity by decreasing spike frequencies. The mean spike frequencies decreased significantly in all the LEV treated groups. There was no significant change in the spike amplitudes of the LEV groups compared with the control group. 40 mg/kg of LEV was determined as the most effective dose on reducing epileptiform activity. The results of this study suggest that LEV is an effective antiepileptic agent in penicillin-induced epilepsy.
Açıklama
Anahtar Kelimeler
epilepsy, penicillin, rat, levetiracetam
Kaynak
Acta Neurobiologiae Experimentalis
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
74
Sayı
3
