Effect of levetiracetam on penicillin induced epileptic activity in rats

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dc.authoridSefil, Fatih/0000-0001-5534-7448
dc.contributor.authorArik, Aliye Erguvan
dc.contributor.authorBagirici, Faruk
dc.contributor.authorSefil, Fatih
dc.contributor.authorMarangoz, Cafer
dc.date.accessioned2024-09-18T20:19:48Z
dc.date.available2024-09-18T20:19:48Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effects of levetiracetam (LEV) on penicillin- induced epileptiform activity in rats. Penicillin was applied intracerebroventricularly (icy) at a dose of 500 IU to induce epileptiform activity. LEV was given intraperitoneally (ip) at doses of 20, 40, 80 mg/kg before penicillin injection. This agent reduced epileptiform activity by decreasing spike frequencies. The mean spike frequencies decreased significantly in all the LEV treated groups. There was no significant change in the spike amplitudes of the LEV groups compared with the control group. 40 mg/kg of LEV was determined as the most effective dose on reducing epileptiform activity. The results of this study suggest that LEV is an effective antiepileptic agent in penicillin-induced epilepsy.en_US
dc.identifier.endpage275en_US
dc.identifier.issn0065-1400
dc.identifier.issn1689-0035
dc.identifier.issue3en_US
dc.identifier.pmid25231846en_US
dc.identifier.scopus2-s2.0-84907216443en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage266en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9859
dc.identifier.volume74en_US
dc.identifier.wosWOS:000342608700004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNencki Inst Experimental Biologyen_US
dc.relation.ispartofActa Neurobiologiae Experimentalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectepilepsyen_US
dc.subjectpenicillinen_US
dc.subjectraten_US
dc.subjectlevetiracetamen_US
dc.titleEffect of levetiracetam on penicillin induced epileptic activity in ratsen_US
dc.typeArticleen_US

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