The Effect of Agomelatine on the Nociceptive System
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
Kure Iletisim Grubu A S
Access Rights
info:eu-repo/semantics/openAccess
Abstract
Objective:The aim of the study was to study the effects of agomelatine, an antidepressant, on the nociceptive. system. Methods: Twenty four male Swiss albino mice (four months old and 28.8 +/- 1.18 g average weight) were randomly divided into three groups, which were equal in numbers; Group A and B were the experimental groups and group C was the control group. Group A was given 12.5 mg/kg of agomelatine, Group B was given 25 mg/kg agomelatine and Group C was given physiological saline via intraperitoneal injection. To evaluate the nociceptive effects, by using the hot plate method (50 degrees C), pain threshold values of the control and agomelatine groups were recorded as the 30th and 60th minute findings. Results: According to the pain threshold results, the datafor the two agomelatine groups were found to be higher than control group at both time points. In 30th minute measurements, between Group B and the other groups, significant differences were observed (p=0.007). In addition, significance in the interaction between time and group was observed (p=0.036). Conclusions: The results of the study suggest that agomelatine might have analgesic efficacy on the nociceptive system in mice.
Description
Keywords
agomelatine, analgesia, antidepressant, hyperalgesia, melatonin, nociceptive system, pain
Journal or Series
Klinik Psikofarmakoloji Bulteni-Bulletin of Clinical Psychopharmacology
WoS Q Value
Q4
Scopus Q Value
N/A
Volume
24
Issue
3
