The Effect of Agomelatine on the Nociceptive System

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dc.authoridERSAN, Yusuf/0000-0002-0065-3656
dc.contributor.authorKivrak, Yuksel
dc.contributor.authorKarademir, Basaran
dc.contributor.authorAygun, Hayati
dc.contributor.authorErsan, Yusuf
dc.contributor.authorAri, Mustafa
dc.contributor.authorKaraahmet, Elif
dc.contributor.authorYagci, Ibrahim
dc.date.accessioned2024-09-18T19:52:30Z
dc.date.available2024-09-18T19:52:30Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective:The aim of the study was to study the effects of agomelatine, an antidepressant, on the nociceptive. system. Methods: Twenty four male Swiss albino mice (four months old and 28.8 +/- 1.18 g average weight) were randomly divided into three groups, which were equal in numbers; Group A and B were the experimental groups and group C was the control group. Group A was given 12.5 mg/kg of agomelatine, Group B was given 25 mg/kg agomelatine and Group C was given physiological saline via intraperitoneal injection. To evaluate the nociceptive effects, by using the hot plate method (50 degrees C), pain threshold values of the control and agomelatine groups were recorded as the 30th and 60th minute findings. Results: According to the pain threshold results, the datafor the two agomelatine groups were found to be higher than control group at both time points. In 30th minute measurements, between Group B and the other groups, significant differences were observed (p=0.007). In addition, significance in the interaction between time and group was observed (p=0.036). Conclusions: The results of the study suggest that agomelatine might have analgesic efficacy on the nociceptive system in mice.en_US
dc.identifier.doi10.5455/bcp.20130925022745
dc.identifier.endpage225en_US
dc.identifier.issn1017-7833
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84907983409en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage220en_US
dc.identifier.urihttps://doi.org/10.5455/bcp.20130925022745
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7470
dc.identifier.volume24en_US
dc.identifier.wosWOS:000345108400004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKure Iletisim Grubu A Sen_US
dc.relation.ispartofKlinik Psikofarmakoloji Bulteni-Bulletin of Clinical Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectagomelatineen_US
dc.subjectanalgesiaen_US
dc.subjectantidepressanten_US
dc.subjecthyperalgesiaen_US
dc.subjectmelatoninen_US
dc.subjectnociceptive systemen_US
dc.subjectpainen_US
dc.titleThe Effect of Agomelatine on the Nociceptive Systemen_US
dc.typeArticleen_US

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