Synergistic activities of the essential oils Hypericum perforatum with methotrexate on human breast cancer cell line MCF-7

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dc.authorscopusid23488666100
dc.authorscopusid35612683100
dc.authorscopusid57196342765
dc.authorscopusid7004487734
dc.authorscopusid57204214637
dc.contributor.authorDuran, Gulay Gulbol
dc.contributor.authorDuran, Nizami
dc.contributor.authorAy, Emrah
dc.contributor.authorKaya, Durmus Alpaslan
dc.contributor.authorKaya, Madalina Georgiana Albu
dc.date.accessioned2024-09-19T15:41:15Z
dc.date.available2024-09-19T15:41:15Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description6th International Conference on Advanced Materials and Systems, ICAMS 2016 -- 20 October 2016 through 22 October 2016 -- Bucharest -- 139798en_US
dc.description.abstractHypericum perforatum (Hypericaceae) is a perennial plant usually known as “Sarikantaron“ that has been reported to have various important biological activities.In this present study, it was aimed to (I) identify the components (ii) show the synergistic activities of the essential oils Hypericum perforatum with methotrexate on human breast cancer cell line MCF-7. A normal [Madin-Darby Bovine Kidney (MDBK) cell line] and a cancer cell line [Human breast adenocarcinoma cell line (MCF-7)] were used in this study. The cell culture were treated with various concentrations of Hypericum perforatum's oils. The cytotoxic activity of the essential oils of Hypericum perforatum on the cell lines was measured using the MTT method and the results were evaluated as IC50. In this study, the presence of trans-caryophyllene, germacrene-D, ?-pinene, trans-cadina-1,4-diene, ?- Selinene, caryophyllene oxide and ?-Selinene were identified as major constituents of Hypericum perforatum's oils. The essential oils of Hypericum perforatum also exhibited anticancer activities against MCF-7 cells. The IC50 values of the essential oils, MTX and the essentialoilsplus MTX weredetermined as 0.78, 6.25 and 0.195 ?g/ml, respectively, But, the essential oils of Hypericum perforatum was found to be non-cytotoxic for MDBK cells. In conclusion, the essential oils of Hypericum perforatum was chemically characterized and ?-muurolene, ?-cadinene, germacrene B, a-copaene, germacrene D, bicyclogermacrene, and (E)-caryophyllene were found to be major constituents. The essential oils of Hypericum perforatum possess significant in vitro anticancer potential. The essential oils of Hypericum perforatum with MTX found to be significant effective against breast cancer cells. Further studies especially in vivo anticancer properties of Hypericum perforatum should be searched. These compounds found to be very promising compounds in the treatment of cancer therapy. © 2016 Certex, INCDTP-ICPI.en_US
dc.identifier.isbn978-194358012-5
dc.identifier.issn2068-0783
dc.identifier.scopus2-s2.0-85047629776en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14130
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCertex, INCDTP-ICPIen_US
dc.relation.ispartofICAMS Proceedings of the International Conference on Advanced Materials and Systemsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticanceren_US
dc.subjectEssential oilen_US
dc.subjectHypericum perforatumen_US
dc.subjectMCF-7 cell lineen_US
dc.subjectSynergistic activityen_US
dc.titleSynergistic activities of the essential oils Hypericum perforatum with methotrexate on human breast cancer cell line MCF-7en_US
dc.typeConference Objecten_US

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