PROTECTIVE EFFECTS OF TIROFIBAN HYDROCHLORIDE, A GLYCOPROTEIN IIB/IIIA INHIBITOR, ON LIVER ISCHEMIA/REPERFUSION INJURY IN RATS

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dc.contributor.authorPaltaci, Ilhan
dc.contributor.authorAydogan, Akin
dc.contributor.authorAkkucuk, Seckin
dc.contributor.authorTemiz, Muhyittin
dc.contributor.authorYetim, Ibrahim
dc.contributor.authorUgur, Mustafa
dc.contributor.authorYonden, Zafer
dc.date.accessioned2024-09-18T20:29:37Z
dc.date.available2024-09-18T20:29:37Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractAims: Both ischemia and reperfusion (IR) can cause damages in cells. There are several studies to eliminate the damage. Tirofiban Hydrochloride (TH) is a common glycoprotein Ilb/IIIa inhibitor and is being used for ischemic disorders for many years. We aimed to determine the therapeutic effects of tirofiban in liver ischemia reperfusion injury model in this animal study. Materials and methods: We induced a 45-minute hepatic ischemia via portal vein, hepatic artery and bile ducts and a 60-minute reperfusion immediately after hepatic ischemia in male albino Wistar rats. One of the groups received intraperitoneal 0.25 mg/ml TH 30 minutes before ischemia and other received intraperitoneal 0.25 mg/ml TH 30 minutes before reperfusion. At the end of the experiment, all animals were decapitated and blood and tissue samples were collected. Results: To evaluate hepatic functions, we assessed serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH). In hepatic tissue samples, catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels were evaluated. We stained hepatic tissue samples with Hematoxylin and Eosin and explored them with a light microscope. Serum AST, ALT, and LDH levels were increased after IR and decreased significantly in the group in which TH was administered. Tissue CAT, SOD, and GSH levels were decreased in IR groups. In TH groups, antioxidant levels were increased when compared to IR groups. Hepatocellular injury that indicates IR-related damage was decreased substantially after TH administration. Conclusion: According to the results of the study, TH decreased the destructive effects of IR. We suggest that TH treatment may can be used in the treatment of hepatic IR damage.en_US
dc.identifier.endpage126en_US
dc.identifier.issn0393-6384
dc.identifier.issue1en_US
dc.identifier.startpage121en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10969
dc.identifier.volume31en_US
dc.identifier.wosWOS:000346319200019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiveren_US
dc.subjectischemia reperfusionen_US
dc.subjectTirofiban Hydrochlorideen_US
dc.subjectantioxidantsen_US
dc.titlePROTECTIVE EFFECTS OF TIROFIBAN HYDROCHLORIDE, A GLYCOPROTEIN IIB/IIIA INHIBITOR, ON LIVER ISCHEMIA/REPERFUSION INJURY IN RATSen_US
dc.typeArticleen_US

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