Effects of accidental ammonium Sulphate poisoning on antioxidant/oxidant status in lambs

Basit Öğe Kaydı
dc.authoridAytekin, Ismail/0000-0001-6794-5453
dc.contributor.authorAytekin, I.
dc.contributor.authorOnmaz, A. C.
dc.contributor.authorUlucan, A.
dc.contributor.authorAlp, H.
dc.date.accessioned2024-09-18T20:29:28Z
dc.date.available2024-09-18T20:29:28Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn this study, the effects of the ammonium sulphate intoxication on the blood antioxidant /oxidant status were investigated in Sakiz crossbred lambs. For that, circulating blood urea nitrogen (BUN), nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH), beta-carotene, retinol and ceruloplasmin concentrations were measured in 6 lambs accidentally poisoned with ammonium sulphate and in 6 healthy control lambs. Oral treatment with 10% glutamic acid (1g/kg), 2.5% acetic acid (2.5 mL/kg) and vitamin A (400 IU/kg) was daily administered to diseased animals for five days. Poisoned lambs exhibited neurological signs (sleepiness, ataxia, tonic and clonic spasms) coupled to a rumen atony and acceleration of heart and respiratory rates compared to healthy controls. Biochemically, the circulating MDA, NO and BUN concentrations were markedly increased and the GSH, beta-carotene and vitamin A concentrations were significantly depressed compared to healthy controls whereas the ceruloplasmin concentrations were not significantly altered. After treatment, clinical and biochemical signs were significantly alleviated but, however 2 lambs died. For them, the histopathological examinations after haematoxylin-eosin staining revealed cell degeneration in liver, lungs and kidney associated to mononuclear cell infiltrates and proliferation of Kiipffer cells. These results clearly showed the occurrence of an oxidative stress induced by ammonium sulphate poisoning leading to cell damage and proved the efficiency of a treatment based on organic acids and retinol supplementation.en_US
dc.identifier.endpage351en_US
dc.identifier.issn0035-1555
dc.identifier.issue7en_US
dc.identifier.startpage346en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10862
dc.identifier.volume162en_US
dc.identifier.wosWOS:000295892300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherEcole Nationale Veterinaire Toulouseen_US
dc.relation.ispartofRevue De Medecine Veterinaireen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLamben_US
dc.subjectammonium sulphateen_US
dc.subjectintoxicationen_US
dc.subjectoxidative stressen_US
dc.subjectnitric oxideen_US
dc.subjectantioxidant depletionen_US
dc.subjectorganic aciden_US
dc.subjectretinolen_US
dc.titleEffects of accidental ammonium Sulphate poisoning on antioxidant/oxidant status in lambsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu