HIV ile enfekte hastalarda periferik nöropati prevalansı
Yükleniyor...
Dosyalar
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Hatay Mustafa Kemal Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada HIV (Human Immuno deficiency Virus) ile enfekte bireylerde periferik nöropati (PN) prevalansının araştırılması amaçlandı. Gereç ve Yöntem: Çalışmamız tek merkezli prospektif olarak gerçekleştirilmiştir. Hatay Mustafa Kemal Üniversitesi Hastanesi Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji polikliniğine başvuran 18-65 yaş aralığında HIV tanısı doğrulanmış toplam 50 hasta dahil edildi. Hastaların demografik (yaş, cinsiyet, boy, medeni durum, eğitim düzeyi, alkol-sigara kullanımı, madde kullanımı, cinsel tercih, ek hastalıkları, kullandığı ilaç), klinik (hastalığın süresi, tedavi süresi, nöropatik ağrı semptomları) ve laboratuvar verileri (HIV RNA düzeyi, CD4+ T lenfosit sayısı, açlık kan şekeri, VDRL-TPHA testi, B12 düzeyi, folat düzeyi, Anti-HCV, kreatinin, trigliserid düzeyi, elektroforez sonuçları) kaydedildi. PN varlığını araştırmak için hastalara elektromiyografi (EMG) yapıldı ve DN4 (Douleur Neuropathique 4 questions) ağrı ölçeği uygulandı. Bulgular: Hastaların 44 (%88,0)'ü erkek, 6 (%12,0)'si kadındı. Yaş ortalaması 37,5±4,0 yıldı. Hastaların 35 (%70,0)'i heteroseksüel, 12 (%24,0)'si homoseksüel, 3 (%6,0)'ü biseksüeldi. Hastaların CD4+T lenfosit hücre sayısı ortalaması 675,96±271,91 hücre/mm3 idi. HIV-RNA'sı negatif olan hasta sayısı 46 (%92,0), HIV-RNA'sı pozitif olan hasta sayısı 4 (%8,0) idi. EMG verilerine göre hastaların 17 (%34,0)'sinde PN tespit edildi. PN tespit edilen 17 hastanın 8 (%47,1)'inde semptom vardı. Kadın hastalarda, 45-65 yaş arası hastalarda ve ilkokul mezunu hastalarda PN daha yüksek sıklıkta saptandı (sırasıyla; p=0,014, p<0,001, p=0,009). DN4 ağrı ölçeğine göre çalışmaya dahil edilen 50 hastanın (%100) 4 ve altında puan aldığı saptandı. Sonuç: Çalışmamızda HIV tanılı hastaların %34'ünde PN saptanmıştır. Kadın hastalarda, 45-65 yaş arası hastalarda ve ilkokul mezunu hastalarda PN görülme oranı daha yüksek bulunmuştur. CD4+T lenfosit sayısı ve HIV-RNA yükü ile PN arasında ilişki bulunamamıştır.
Aims: In this study, it was aimed to investigate the prevalence of peripheral neuropathy (PN) in HIV-infected individuals. Materials and Methods: Our study was conducted as a single-center, prospective study. A total of 50 patients aged 18-65 years who applied to Hatay Mustafa Kemal University Hospital Infectious Diseases and Clinical Microbiology outpatient clinic with confirmed HIV diagnosis were included. Demographic (age, gender, height, marital status, education level, alcohol-smoking use, substance use, sexual preference, co-morbidities, medication), clinical (duration of the disease, duration of treatment, neuropathic pain symptoms) and laboratory data of the patients ( HIV RNA level, CD4+ T lymphocyte count, fasting blood glucose, VDRL-TPHA test, B12 level, folate level, Anti-HCV, creatinine, triglyceride level, electrophoresis results) were recorded in an excel file. Electromyography (EMG) was performed on the patients to investigate the presence of PN. The DN4 (Douleur Neuropathique 4 questions) pain scale was applied. Results: Forty-four (88.0%) patients were male and 6 (12.0%) were female. The mean age was 37.5±4.0 years. Of the patients, 35 (70.0%) were heterosexual, 12 (24.0%) were homosexual, and 3 (6.0%) were bisexual. The mean CD4+T lymphocyte cell count of the patients was 675.96±271.91 cells/mm3.The number of HIV-RNA negative patients was 46 (92.0%), and the number of HIV-RNA positive patients was 4 (8.0%). According to EMG data, PN was detected in 17 (34.0%) of the patients. Eight (47.1%) of 17 patients with PN had symptoms. PN was found to be higher in female patients, patients aged 45-65 years, and patients who graduated from primary school (p=0.014, p<0.001, p=0.009, respectively). According to the DN4 pain scale, 50 patients (100%) included in the study scored 4 or less. Conclusion: In our study, PN was found in 34% of HIV-diagnosed patients. The incidence of PN was found to be higher in female patients, patients aged 45-65, and primary school graduates. No correlation was found between CD4+T lymphocyte count and HIV-RNA load and PN. Key words: HIV infection, peripheral neuropathy, electromyography, DN4
Aims: In this study, it was aimed to investigate the prevalence of peripheral neuropathy (PN) in HIV-infected individuals. Materials and Methods: Our study was conducted as a single-center, prospective study. A total of 50 patients aged 18-65 years who applied to Hatay Mustafa Kemal University Hospital Infectious Diseases and Clinical Microbiology outpatient clinic with confirmed HIV diagnosis were included. Demographic (age, gender, height, marital status, education level, alcohol-smoking use, substance use, sexual preference, co-morbidities, medication), clinical (duration of the disease, duration of treatment, neuropathic pain symptoms) and laboratory data of the patients ( HIV RNA level, CD4+ T lymphocyte count, fasting blood glucose, VDRL-TPHA test, B12 level, folate level, Anti-HCV, creatinine, triglyceride level, electrophoresis results) were recorded in an excel file. Electromyography (EMG) was performed on the patients to investigate the presence of PN. The DN4 (Douleur Neuropathique 4 questions) pain scale was applied. Results: Forty-four (88.0%) patients were male and 6 (12.0%) were female. The mean age was 37.5±4.0 years. Of the patients, 35 (70.0%) were heterosexual, 12 (24.0%) were homosexual, and 3 (6.0%) were bisexual. The mean CD4+T lymphocyte cell count of the patients was 675.96±271.91 cells/mm3.The number of HIV-RNA negative patients was 46 (92.0%), and the number of HIV-RNA positive patients was 4 (8.0%). According to EMG data, PN was detected in 17 (34.0%) of the patients. Eight (47.1%) of 17 patients with PN had symptoms. PN was found to be higher in female patients, patients aged 45-65 years, and patients who graduated from primary school (p=0.014, p<0.001, p=0.009, respectively). According to the DN4 pain scale, 50 patients (100%) included in the study scored 4 or less. Conclusion: In our study, PN was found in 34% of HIV-diagnosed patients. The incidence of PN was found to be higher in female patients, patients aged 45-65, and primary school graduates. No correlation was found between CD4+T lymphocyte count and HIV-RNA load and PN. Key words: HIV infection, peripheral neuropathy, electromyography, DN4
Açıklama
Anahtar Kelimeler
Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji, Infectious Diseases and Clinical Microbiology, HIV enfeksiyonu, periferik nöropati, elektromiyografi, DN4
