Carrying system formula for eugenol encapsulation: glycodendritic polyamine dextran-G2.5, synthesis and in vitro antibacterial activity
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A novel 2.5th-generation glycodendritic polyamine dextran with 96 arms (DPADx) was synthesized by the divergent method. 2.5th-generation dendrimer was obtained from the successive triplicate Michael addition with two amidation reactions using 0.5th-generation tris(2-aminoethyl)amine (TAEA-G0.5) as the initiator core. 2.5th-generation polyamine hydrazide (PAH) was obtained from hydrazine monohydrate. Finally, dextran was conjugated with PAH and so DPADx was obtained. FTIR, H-1- and C-13-NMR, elemental analysis, GPC, XRD, SEM, TGA, DSC and dynamic viscosity were used for structural analysis of products. Loading efficiency, capacity and yield (%) of eugenol-encapsulated glycodendrimer were calculated as 70%, 84% and 35%, respectively; by using UV-Vis analysis results, antimicrobial activity against Gram-positive (Staphylococcus aureus, Listeria monocytogenes and Enterococcus cesseliflour) and Gram-negative (Escherichia coli and Salmonella Typhimurium) bacteria was proven. The current study demonstrated the usability of the novel dendritic glycopolymer as an innovative and environmentally friendly way to encapsulate and shuttle of EOs without altering sensory characteristics and the functionality of these molecules. Therefore, its commercial application is possible in a variety of fields, such as pharmaceutic and cosmetic industries.
Açıklama
Anahtar Kelimeler
Dendrimer, Polyamine dextran, Essential oil, Eugenol, Antimicrobial activity
Kaynak
Polymer Bulletin
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
78
Sayı
2
