Carrying system formula for eugenol encapsulation: glycodendritic polyamine dextran-G2.5, synthesis and in vitro antibacterial activity

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dc.authorid, Celile/0000-0002-0534-8933
dc.contributor.authorBucak, Celile Demirbilek
dc.contributor.authorKurekci, Cemil
dc.contributor.authorDinc, Cemile Ozdemir
dc.date.accessioned2024-09-18T20:15:04Z
dc.date.available2024-09-18T20:15:04Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractA novel 2.5th-generation glycodendritic polyamine dextran with 96 arms (DPADx) was synthesized by the divergent method. 2.5th-generation dendrimer was obtained from the successive triplicate Michael addition with two amidation reactions using 0.5th-generation tris(2-aminoethyl)amine (TAEA-G0.5) as the initiator core. 2.5th-generation polyamine hydrazide (PAH) was obtained from hydrazine monohydrate. Finally, dextran was conjugated with PAH and so DPADx was obtained. FTIR, H-1- and C-13-NMR, elemental analysis, GPC, XRD, SEM, TGA, DSC and dynamic viscosity were used for structural analysis of products. Loading efficiency, capacity and yield (%) of eugenol-encapsulated glycodendrimer were calculated as 70%, 84% and 35%, respectively; by using UV-Vis analysis results, antimicrobial activity against Gram-positive (Staphylococcus aureus, Listeria monocytogenes and Enterococcus cesseliflour) and Gram-negative (Escherichia coli and Salmonella Typhimurium) bacteria was proven. The current study demonstrated the usability of the novel dendritic glycopolymer as an innovative and environmentally friendly way to encapsulate and shuttle of EOs without altering sensory characteristics and the functionality of these molecules. Therefore, its commercial application is possible in a variety of fields, such as pharmaceutic and cosmetic industries.en_US
dc.description.sponsorshipHatay Mustafa Kemal University [Scientific Research Project Unit (BAP)] [9980]en_US
dc.description.sponsorshipThe authors thank Hatay Mustafa Kemal University [Scientific Research Project Unit (BAP), (9980)] for financial assistance.en_US
dc.identifier.doi10.1007/s00289-020-03125-3
dc.identifier.endpage620en_US
dc.identifier.issn0170-0839
dc.identifier.issn1436-2449
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85079732897en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage601en_US
dc.identifier.urihttps://doi.org/10.1007/s00289-020-03125-3
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9427
dc.identifier.volume78en_US
dc.identifier.wosWOS:000516175200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPolymer Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDendrimeren_US
dc.subjectPolyamine dextranen_US
dc.subjectEssential oilen_US
dc.subjectEugenolen_US
dc.subjectAntimicrobial activityen_US
dc.titleCarrying system formula for eugenol encapsulation: glycodendritic polyamine dextran-G2.5, synthesis and in vitro antibacterial activityen_US
dc.typeArticleen_US

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