Usefulness of (1?3)-b-D glucan in early diagnosing Pneumocystis jirovecii pneumonia: A case report
[ N/A ]
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
EDIMES Edizioni Medico Scientifiche
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Pneumocystis jirovecii pneumoniae (PJP) may be difficult to diagnose. Since pneumocystis cannot be cultured, the diagnosis of PJP requires microscopic examination to identify pneumocystis from induced sputum or bronchoalveolar lavage (BAL) fluid. In order to evaluate the usefulness of (1{squared times}3) ß- D-glucan (BDG) levels in the early diagnosis of PJP, we describe the case of PJP in a 25-year-old male with acute lymphoblastic leukaemia (ALL) admitted to hospital with progressive dyspnea and fever with chills. The patient was not infected with human immunodeficiency virus (HIV). Sputum, blood, and urine cultures were negative; smears for acid-fast bacilli and tests for viral antibodies were both negative. The microbiology study of the BAL with Giemsa and immunofluorescence staining, seven days after admission showed the existence of P. jiroveci in the lungs. Further, one day and five days after admission, (1{squared times}3) ß-D-glucan (BDG) levels were very high. The high serum level of BDG considerably decreased after treatment with trimethoprim-sulfamethoxazole (TMPSMX) and the clinical condition of the patient increasingly improved.
Açıklama
Anahtar Kelimeler
beta-Glucans, Early Diagnosis, Humans, Male, Pneumocystis jirovecii, Pneumonia, Pneumocystis, Young Adult, aminophylline, beta 1, 3 glucan, cefepime, clarithromycin, cotrimoxazole, dexamethasone, granulocyte colony stimulating factor, levofloxacin, unclassified drug, beta glucan, beta-1,3-D-glucan, adult, article, case report, dyspnea, fever, follow up, Giemsa stain, human, human tissue, immunofluorescence test, lung lavage, lung mycosis, male, myeloid leukemia, neutropenia, oxygen therapy, Pneumocystis jiroveci, wheezing, young adult, blood, early diagnosis, Pneumonia, Pneumocystis
Kaynak
Infezioni in Medicina
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
22
Sayı
1
