Molecular, biochemical, and histopathological effects of long-term low and high-percentage fructose consumption on the liver in rats

Basit Öğe Kaydı
dc.authoridOzkan, Huseyin/0000-0001-5753-8985
dc.authoridOzsoy, Sule Yurdagul/0000-0003-4254-7146
dc.contributor.authorOzkan, Huseyin
dc.contributor.authorKutlu, Tuncer
dc.contributor.authorYakin, Akin
dc.contributor.authorOzsoy, Sule Yurdagul
dc.date.accessioned2024-09-18T20:20:03Z
dc.date.available2024-09-18T20:20:03Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the lipogenic and inflammatory effects of low and high percentage fructose solutions in rats. Wistar albino rats were fed with fructose solutions for 10 weeks. The groups were as follows: Cont (Control), F15 (Fructose 15%), F30 (Fructose 30%), and F60 (Fructose 60%). Rats' body weights were measured weekly. Also, lipogenic and inflammatory gene expression levels, biochemical parameters, and histopathological changes in the liver were investigated. After 10 weeks, it was observed that the animals in the F60 were the heaviest, while the animals in the F30 were the lightest. In all experimental groups, triglycerides were significantly higher than those of controls (P<0.05). In F30 and F60, TNF alpha, IL-6, and IL-1/1 were upregulated in the liver compared to control (P<0.05). In addition, SREBP-1c, ChREBP, FAS, ACACA, and SCD-1 were upregulated in all fructose feeding groups compared to Cont (P<0.05). The livers of rats in the F30 and F60 groups had degenerative changes and steatosis. The most detrimental effects of fructose were observed in F60. The concentration of fructose was found to be a very important factor for maintaining normal liver physiology at the molecular level.en_US
dc.description.sponsorshipTUBITAK; [118O381]en_US
dc.description.sponsorshipFinancial Support This study was financially supported by TUBITAK with 118O381 project number.en_US
dc.identifier.doi10.33988/auvfd.855124
dc.identifier.endpage417en_US
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85143234176en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage409en_US
dc.identifier.trdizinid1127520en_US
dc.identifier.urihttps://doi.org/10.33988/auvfd.855124
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1127520
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10028
dc.identifier.volume69en_US
dc.identifier.wosWOS:000869793900009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAnkara Univ Pressen_US
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFatty liveren_US
dc.subjectfructoseen_US
dc.subjectinflammationen_US
dc.subjectlipogenesisen_US
dc.subjectNAFLDen_US
dc.titleMolecular, biochemical, and histopathological effects of long-term low and high-percentage fructose consumption on the liver in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Tam Metin / Full Text
Boyut:
708.53 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu