Nasobiliary Drainage for Benign Recurrent Intrahepatic Cholestasis in Patients Refractory to Standard Terapy
[ N/A ]
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
The Canadian Society for Clinical Investigation
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: Benign recurrent intrahepatic cholestasis (BRIC) is characterized by episodic cholestasis and pruritus without anatomical obstruction. Te aim of this study was to evaluate the safety and efcacy of nasobiliary drainage (NBD) in patients with BRIC refractory to medical therapy and to determine whether the use of NBD prolongs the episode duration. Methods: Tis was a multicenter retrospective study consisting of 33 patients sufering from BRIC. All patients were administrated medical treatment and 16 patients who were refractory to standard medical therapies improved on treatment with temporary endoscopic NBD. Duration of treatment response and associated complications were analyzed. Results: Sixteen patients (43% females) underwent 25 NBD procedures. Te median duration of NBD was 17 days. Tere were signifcant improvements in total and direct bilirubin and alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase on the 3rd day of NBD. Longer clinical remission was monitored in the NBD group. Post-endoscopic retrograde cholangiopancreatography pancreatitis was observed in one of 16 cases. Conclusion: NBD efectively eliminates BRIC in all patients and improves biomarkers of cholestasis. It can be suggested that patients with attacks of BRIC can be treated with temporary endoscopic NBD; however, the results of this study should be confrmed by prospective studies in the future © 2016. CIM
Açıklama
Anahtar Kelimeler
Adolescent, Adult, Cholangiopancreatography, Endoscopic Retrograde, Cholestasis, Intrahepatic, Female, Humans, Male, Pruritus, Retrospective Studies, adolescent, adult, Cholestasis, Intrahepatic, clinical trial, complication, diagnostic imaging, endoscopic retrograde cholangiopancreatography, female, human, male, multicenter study, pruritus, retrospective study
Kaynak
Clinical and Investigative Medicine
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
39
Sayı
6
