Nasobiliary Drainage for Benign Recurrent Intrahepatic Cholestasis in Patients Refractory to Standard Terapy

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dc.authorscopusid24470317500
dc.authorscopusid58602450200
dc.authorscopusid16028620600
dc.authorscopusid57193009316
dc.authorscopusid25641781500
dc.authorscopusid35796175800
dc.authorscopusid7004054394
dc.contributor.authorYakar, Tolga
dc.contributor.authorDemir, Mehmet
dc.contributor.authorGokturk, Huseyin S.
dc.contributor.authorKanat, Ayse G. Unler
dc.contributor.authorParlakgumus, Alper
dc.contributor.authorOzer, Birol
dc.contributor.authorSerin, Ender
dc.date.accessioned2024-09-19T15:49:43Z
dc.date.available2024-09-19T15:49:43Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: Benign recurrent intrahepatic cholestasis (BRIC) is characterized by episodic cholestasis and pruritus without anatomical obstruction. Te aim of this study was to evaluate the safety and efcacy of nasobiliary drainage (NBD) in patients with BRIC refractory to medical therapy and to determine whether the use of NBD prolongs the episode duration. Methods: Tis was a multicenter retrospective study consisting of 33 patients sufering from BRIC. All patients were administrated medical treatment and 16 patients who were refractory to standard medical therapies improved on treatment with temporary endoscopic NBD. Duration of treatment response and associated complications were analyzed. Results: Sixteen patients (43% females) underwent 25 NBD procedures. Te median duration of NBD was 17 days. Tere were signifcant improvements in total and direct bilirubin and alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase on the 3rd day of NBD. Longer clinical remission was monitored in the NBD group. Post-endoscopic retrograde cholangiopancreatography pancreatitis was observed in one of 16 cases. Conclusion: NBD efectively eliminates BRIC in all patients and improves biomarkers of cholestasis. It can be suggested that patients with attacks of BRIC can be treated with temporary endoscopic NBD; however, the results of this study should be confrmed by prospective studies in the future © 2016. CIMen_US
dc.identifier.doi10.25011/CIM.V39I6.27522
dc.identifier.endpage172en_US
dc.identifier.issn0147-958X
dc.identifier.issue6en_US
dc.identifier.pmid27917812en_US
dc.identifier.scopus2-s2.0-85047594828en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage164en_US
dc.identifier.urihttps://doi.org/10.25011/CIM.V39I6.27522
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15357
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherThe Canadian Society for Clinical Investigationen_US
dc.relation.ispartofClinical and Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectCholangiopancreatography, Endoscopic Retrogradeen_US
dc.subjectCholestasis, Intrahepaticen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectPruritusen_US
dc.subjectRetrospective Studiesen_US
dc.subjectadolescenten_US
dc.subjectadulten_US
dc.subjectCholestasis, Intrahepaticen_US
dc.subjectclinical trialen_US
dc.subjectcomplicationen_US
dc.subjectdiagnostic imagingen_US
dc.subjectendoscopic retrograde cholangiopancreatographyen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectmaleen_US
dc.subjectmulticenter studyen_US
dc.subjectpruritusen_US
dc.subjectretrospective studyen_US
dc.titleNasobiliary Drainage for Benign Recurrent Intrahepatic Cholestasis in Patients Refractory to Standard Terapyen_US
dc.typeArticleen_US

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